Institut de Chimie Moléculaire et des Matériaux d'Orsay

Valerie Alezra

Enseignant-Chercheur
Build. 670, office 1312 – MSMT – ICMMO - UMR 8182
Université Paris-Saclay
Bâtiment 670
17-19 Avenue des Sciences
91400 Orsay
FRANCE

+33 1 69 15 71 95
valerie.alezra@u-psud.fr

Employment

Since Sept. 2020: Associate Professor in Organic Chemistry at Université Paris-Saclay, Orsay.
Research in organic synthesis in Pr. Cyrille Kouklovsky group (ICMMO, UMR 8182).

Jan. 2020 - Aug. 2020: Team leader at Nexdot R&D, Romainville.

Sept. 2018 - Dec. 2019: Researcher at Ynsect, Evry.

Sept. 2003 - Aug. 2018: Associate Professor in Organic Chemistry at Université – Paris Sud, Orsay.
Research in organic synthesis in Pr. Cyrille Kouklovsky group (ICMMO, UMR 8182).
November 2014-February 2015 : "Visiting Associate Professor" at Kyoto University, Japan, in Pr. T. Kawabata's laboratory .
HDR diploma (habilitation to conduct research) in November 2009.

Sept. 2001 - Aug. 2003
Associate Professor in Organic Chemistry at Ecole Normale Supérieure de Lyon ; research in bio-organic chemsitry in Pr. J. Hasserodt group(laboratoire de Stéréochimie et des Interactions Moléculaires – UMR 5532).

Oct. 2000 - Sept. 2001 Post-doc in Pr. E. P. Kündig group, université de Genève : "Synthesis of new chiral Lewis Acids and application to asymmetric catalysis".

Oct. 1997 - Sept. 2000 Ph.D. in organic chemistry under the supervision of Pr. H.-P. Husson (laboratoire de Chimie Thérapeutique, UMR 8638, Faculté de Pharmacie, Paris V).
"New accesses to enantiopure α-substituted serines starting from aziridino-esters or oxazolidino-esters".

Recent papers

Rapid Formation of Intramolecular Disulfide Bridges using Light: An Efficient Method to Control the Conformation and Function of Bioactive Peptides. F. He, Y. Chai, Z. Zeng, F. Lu, H. Chen, J. Zhu, Y. Fang, K. Cheng, E. Miclet, V. Alezra, Y. Wan, J. Am. Chem. Soc., 2023, 145, 22639-22648

Diversity in the Synthesis of Functionalized Cyclohexene Oxide Derivatives by a Cycloaddition–Fragmentation Sequence from Benzene Oxide. F. Rambaud, R. Guillot, V. Alezra, C. Kouklovsky, J. Org. Chem., 2023, 88, 7152-7161

Using the Noncanonical Metallo-Amino Acid [Cu(II)(2,2′-Bipyridin-5-yl)]-alanine to Study the Structures of Proteins. L. C. Tabares, D. T. Daniel, J. L. Vasquez-Ibar, C. Kouklovsky, V. Alezra, S. Un, J. Phys. Chem. Lett., 2023, 14, 3368-3375

Customized Reversible Stapling for Selective Delivery of Bioactive Peptides. Z. Zeng, J. Zhu, X. Deng, H. Chen, Y. Jin, E. Miclet, V. Alezra, Y. Wan, J. Am. Chem. Soc., 2022, 144, 23614-23621

Polymyxin B-inspired non-hemolytic tyrocidine A analogues with significantly enhanced activity against gram-negative bacteria: How cationicity impacts cell specificity and antibacterial mechanism. J. Zhu, C. Hu, Z. Zeng, X. Deng, L. Zeng, S. Xie, Y. Fang, Y. Jin, V. Alezra, Y. Wan, European Journal of Medicinal Chemistry, 2021, 221, 113488

Highly stereoselective aldol reactions by Memory of Chirality: synthesis of quaternary β-hydroxy α-amino acids. L. Roupnel, R. Guillot, D. Gori, B. Viswambharan, C. Kouklovsky, V. Alezra, Helv. Chim. Act., 2021, 104, e2100127

Gramicidin-S-Inspired Cyclopeptidomimetics as Potent Membrane-Active Bactericidal Agents with Therapeutic Potential. C. Hu, Q. Wen, S. Huang, S. Xie, Y. Fang, Y. Jin, R. Campagne, V. Alezra, E. Miclet, J. Zhu, Y. Wan, ChemMedChem, 2021, 16, 368-376

Development of Therapeutic Gramicidin S Analogues Bearing Plastic β,γ-Diamino Acids. Q. Guan, K. Chen, Q. Chen, J. Hu, K. Cheng, C. Hu, J. Zhu, Y. Jin, E. Miclet, V. Alezra, Y. Wan, ChemMedChem, 2020, 15, 1089-1100

Unexpected dimerization of a tripeptide comprising a β,γ-diamino acid. Y. Wan, J.-P. Baltaze, C. Kouklovsky, E. Miclet, V. Alezra, Journal of Peptide Science, 2019, 25, e3143

Recent Advances in the Exploration of Therapeutic Analogues of Gramicidin S, an Old but Still Potent Antimicrobial Peptide. Q. Guan, S. Huang, Y. Jin, R. Campagne, V. Alezra, Y. Wan, J. Med. Chem., 2019, 62, 7603-7617

Memory of Chirality in a Flow-Based System: Enantioselective Synthesis of Quaternary α-Amino Acids Using Flow Microreactors. A. Mambrini, D. Gori, C. Kouklovsky, H. Kim, J.-I. Yoshida, V. Alezra, European Journal of Organic Chemistry, 2018, 6754-6757

Oxidative coupling of enolates using memory of chirality: an original enantioselective synthesis of quaternary α-amino acid derivatives. A. Mambrini, D. Gori, R. Guillot, C. Kouklovsky, V. Alezra, Chem. Commun., 2018, 54, 12742-12745

Constrained Cyclic β,γ-Diamino Acids from Glutamic Acid: Synthesis of Both Diastereomers and Unexpected Kinetic Resolution. Y. Wan, N. Auberger, S. Thétiot-Laurent, F. Bouillère, A. Zulauf, J. He, S. Courtiol-Legourd, R. Guillot, C. Kouklovsky, S. Cote Des Combes, C. Pacaud, I. Devillers, V. Alezra, European Journal of Organic Chemistry, 2018, 329-340

Base mediated fragmentation of bicyclic dihydro-3,6-oxazines: transformation of nitroso Diels-Alder cycloadducts. R. Campagne, F. Schäkel, R. Guillot, V. Alezra, C. Kouklovsky, Org. Lett., 2018, 20, 1884-1887

β,γ-Diamino acids as building blocks for new analogues of Gramicidin S: synthesis and biological activity. Y. Wan, A. Stanovych, D. Gori, S. Zirah, C. Kouklovsky, V. Alezra, Eur. J. Med. Chem., 2018, 149, 122-128.

Interfering peptides targeting protein–protein interactions: the next generation of drugs? H. Bruzzoni-Giovanelli, V. Alezra, N. Wolff, C.-Z. Dong, P. Tuffery, A. Rebollo, Drug Discovery Today, 2018, 23, 272-285

Frozen Chirality of Tertiary Aromatic Amides :Access to Enantioenriched Tertiary alpha-Amino Acid or Amino Alcohol without Chiral Reagent. T. T. Mai, B. Viswambharan, D. Gori, R. Guillot, J.-V. Naubron, C. Kouklovsky, V. Alezra, Chem. Eur. J., 2017, 23, 5787-5798

Recent Progress in Memory Of Chirality (MOC): An Advanced Chiral Pool. V. Alezra, T. Kawabata, Synthesis, 2016, 48, 2997-3016

Efficient synthesis of both diastereomers of β,γ-diamino acids from phenylalanine and tryptophan. N. Auberger, A. Stanovych, S. Thétiot-Laurent, R. Guillot, C. Kouklovsky, S. Cote Des Combes, C. Pacaud, I. Devillers, V. Alezra, Amino Acids, 2016, 48(9), 2237-2242

Substrate Control in Enantioselective and Diastereoselective Aldol Reaction by Memory of Chirality: A Rapid Access to Enantiopure β-Hydroxy Quaternary α-Amino Acids. B. Viswambharan, D. Gori, R. Guillot, C. Kouklovsky, V. Alezra, Org. Lett., 2014, 16, 788-791

β,γ-Diamino acid: an original building block for hybrid α/γ-peptide synthesis with extra hydrogen bond donating group. A. Stanovych, R. Guillot, C. Kouklovsky, E. Miclet, V. Alezra, Amino Acids, 2014, 46, 2753-2757