Institut de Chimie Moléculaire et des Matériaux d'Orsay

Frédéric Avenier

Bât. 420LCBB – ICMMO
Université Paris-Saclay
Rue du doyen Georges Poitou
91405 Orsay Cedex

+33 1 69 15 47 23

Education and positions

"Habilitation à Diriger des Recherches" from Université Paris Sud (September 03 2017)

Since 2009 : University Lecturer at Université Paris Sud

2008-2009 : ATER (Postdoc) at ENS Lyon, Bioorganic chemistry Lab (Prof. Hasserodt).

2004-2008 : Postdoc at the University of Cambridge, UK, Department of Biochemistry (Prof. Hollfelder).

2000-2003 : PhD in Molecular Chemistry at Université Joseph Fourier, Grenoble (Supervisor: Dr. Jean-Marc Latour).


Selected Publications

Selective Formation of an FeIVO or an FeIIIOOH Intermediate From FeII-H2O2: Controlled Heterolytic vsHomolytic O-O Bond Cleavage by the Second Coordination Sphere

Angew. Chem. Int. Ed. 2019, 58, 854-858

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Aerobic Baeyer-Villiger Oxidation Catalyzed by a Flavin-Containing Enzyme Mimic in Water 

Angew. Chem. Int. Ed. 2018, 57, 16412-16415

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A Growing Family of OActivating Dinuclear Iron Enzymes with Key Catalytic Diiron(III)-peroxo Intermediates: Biological Systems and Chemical Models

Coord. Chem. Rev. 2016, 322, 142-158

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Bio-inspired electron-delivering system for reductive activation of dioxygen at metal centres towards artificial flavoenzymes

Nature Communications 2015, 6, 8509

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List of publications since 2013

Experiments and DFT Computations Combine to Decipher Fe-Catalyzed Amidine Synthesis through Nitrene Transfer and Nitrile Insertion. G. Coin, P. Dubourdeaux, F. Avenier, R. Patra, L. Castro, C. Lebrun, P.-A. Bayle, J. Pécaut, G. Blondin, P. Maldivi, J.-M. Latour, ACS Catalysis, 2021, 2253-2266

Recent progress in the development of new artificial metalloenzymes as biocatalysts for selective oxidations and Diels-Alder reaction - Mini-Review. F. Avenier, W. Ghattas, R. Ricoux, J.-P. Mahy, Vietnam J. Chem., 2020, 58, 423-433

Bioinspired Symmetrical and Unsymmetrical Diiron Complexes for Selective Oxidation Catalysis with Hydrogen Peroxide. A. Trehoux, R. Guillot, M. Clémancey, G. Blondin, J.-M. Latour, J.-P. Mahy, F. Avenier, Dalton Trans., 2020, 49, 16657-16661

Characterization in Aqueous Medium of an FMN Semiquinone Radical Stabilized by the Enzyme-Like Microenvironment of a Modified Polyethyleneimine. Y. Chevalier, Y. L. T. Ki, C. Herrero, D. L. Nouen, J.-P. Mahy, J.-P. Goddard, F. Avenier, Org. Biomol. Chem., 2020, 18, 4386-4389

Aerobic Oxidation Catalyzed by Polyoxometalates Associated to an Artificial Reductase at Room Temperature and in Water. A. Naim, Y. Chevalier, Y. Bouzidi, P. Gairola, P. Mialane, A. Dolbecq-Bastin, F. Avenier, J.-P. Mahy, Inorg. Chem. Frontiers, 2020, 7, 2362-2369

Artificial iron hydrogenase made by covalent grafting of Knölker's complex into xylanase: Application in asymmetric hydrogenation of an aryl ketone in water. K. Kariyawasam, W. Ghattas, Y. L. D. L. Santos, N. Doucet, S. Gaillard, J.-L. Renaud, F. Avenier, J.-P. Mahy, R. Ricoux, Biotechnol. Appl. Biochem., 2020, 67, 563-573

Selective Formation of an FeIVO or an FeIIIOOH Intermediate From FeII-H2O2 : Controlled Heterolytic vs Homolytic O-O Bond Cleavage by the Second Coordination Sphere. K. Cheaib, M. Q. E. Mubarak, K. Sénéchal-David, C. Herrero, R. Guillot, M. Clémancey, J.-M. Latour, S. D. Visser, J.-P. Mahy, F. Banse, F. Avenier, Angew. Chem. Int. Ed., 2019, 58, 854-858

Aerobic Baeyer-Villiger Oxidation Catalyzed by a Flavin-Containing Enzyme Mimic in Water. Y. Chevalier, Y. L. T. Ki, D. L. Nouen, J.-P. Mahy, J.-P. Goddard, F. Avenier, Angew. Chem. Intern. Ed., 2018, 57, 16412-16415

Imidazolidine Ring Cleavage upon Complexation with First Row Transition Metals. K. Cheaib, C. Herrero, R. Guillot, F. Banse, J.-P. Mahy, F. Avenier, Eur. J. Inorg. Chem., 2017, 3884-3891

Redox Self-Adaptation of a Nitrene Transfer Catalyst to the Substrate Needs. E. Gouré, D. Senthilnathan, G. Coin, F. Albrieux, F. Avenier, P. Dubourdeaux, C. Lebrun, P. Maldivi, J.-M. Latour, Angew. Chem. Intern. Ed., 2017, 56, 4305-4309

Elucidating the light-induced charge accumulation in an artificial analogue of methane monooxygenase enzymes using time-resolved x-ray absorption spectroscopy. D. Moonshiram, A. Picon, Á. Vázquez-Mayagoitia, X. Zhang, M.-F. Tu, P. Garrido-Barros, J.-P. Mahy, F. Avenier, A. Aukauloo, Chem. Commun., 2017, 53, 2725-2728

Reduction of a Tris(picolyl)amine Copper(II) Complex by an Polymeric Flavo-Reductase model in Water. K. Cheaib, Y. Roux, C. Herrero, A. Trehoux, F. Avenier, J.-P. Mahy, Dalton Trans., 2016, 45, 18098-18101

A growing family of o2 activating dinuclear iron enzymes with key catalytic diiron(III)-peroxo intermediates: biological systems and chemical models. A. Trehoux, J.-P. Mahy, F. Avenier, Coord. Chem. Rev., 2016, 322, 142-158

Bio-inspired electron-delivering system for reductive activation of dioxygen at metal centres towards artificial flavoenzymes. Y. Roux, R. Ricoux, F. Avenier, J.-P. Mahy, Nature Communications, 2015, 6, 8509

Synthesis and characterization of [Fe(BPMEN)ACC]SbF₆: a structural and functional mimic of ACC-oxidase. Y. Roux, W. Ghattas, F. Avenier, R. Guillot, A. J. Simaan, J.-P. Mahy, Dalton Trans., 2015, 44, 5966-5968

Catalytic oxidation of dibenzothiophene and thioanisole by a diiron(III) complex and hydrogen peroxide. A. Trehoux, Y. Roux, R. Guillot, J.-P. Mahy, F. Avenier, Journal of Molecular Catalysis A: Chemical, 2015, 396, 40-46

Neocarzinostatin-based hybrid biocatalysts with a RNase like activity. A. Urvoas, W. Ghattas, J.-D. Maréchal, F. Avenier, F. Bellande, W. Mao, R. Ricoux, J.-P. Mahy, Bioorg. Med. Chem., 2014, 22, 5678-5686

Photoassisted Generation of a Dinuclear Iron(III) Peroxo Species and Oxygen-Atom Transfer. F. Avenier, C. Herrero, W. Leibl, A. Desbois, R. Guillot, J.-P. Mahy, A. Aukauloo, Angew. Chem. Intern. Ed., 2013, 52, 3634-3637