Publications

Méthodologie, Synthèse et Molécules Thérapeutiques

Publications de l'équipe

2024

Ferrocene-Mediated Electrochemical Polycyclization of Malonates. A. Lefevre, R. Guillot, C. Kouklovsky, G. Vincent, Org. Lett., 2024

Regio- and Chemoselective Double Allylic Substitution of Alkenyl vic-Diols. B. Chen, L. Pagès, R. Dollet, C. Kouklovsky, S. Prévost, A. De La Torre, Org. Lett., 2024, 26, 2393-2397

Total Synthesis of Mavacuran Alkaloids via Bioinspired and Non-Bioinspired Strategies. C. Kouklovsky, E. Poupon, L. Evanno, G. Vincent, Synlett, 2024, 35, 521-534

2023

Natural Product Synthesis: The Endless Quest for Unreachable Perfection. N. Fay, C. Kouklovsky, A. De La Torre, ACS Org. Inorg. Au, 2023, 3, 350-363

Total Synthesis of Lucidumone: Attempted Shortcuts, Dead Ends and Lessons Learnt. G. Huang, A. Laporte, L. Pagès, C. Kouklovsky, A. De La Torre, Synthesis, 2023, 55, A-H

Rapid Formation of Intramolecular Disulfide Bridges using Light: An Efficient Method to Control the Conformation and Function of Bioactive Peptides. F. He, Y. Chai, Z. Zeng, F. Lu, H. Chen, J. Zhu, Y. Fang, K. Cheng, E. Miclet, V. Alezra, Y. Wan, J. Am. Chem. Soc., 2023, 145, 22639-22648

Retro-[4+2]/Intramolecular Diels–Alder Cascade Allows a Concise Total Synthesis of Lucidumone. G. Huang, C. Kouklovsky, A. De La Torre, Synlett, 2023, 34, 1195-1199

Functional and structural insights into human N-deacetylase/N-sulfotransferase activities. S. D. Vallet, T. Annaval, R. R. Vivès, J. Hénault, C. Le Narvor, D. Bonnaffé, B. Priem, R. Wild, H. Lortat-Jacob, Proteoglycan Research, 2023, 1, e8

Benzylic C-H Arylation with Dicyanoarenes via Convergent Paired Electrolysis. S. Tang, G. Vincent, Green Chem., 2023, 25, 5483–5488

Diversity in the Synthesis of Functionalized Cyclohexene Oxide Derivatives by a Cycloaddition–Fragmentation Sequence from Benzene Oxide. F. Rambaud, R. Guillot, V. Alezra, C. Kouklovsky, J. Org. Chem., 2023, 88, 7152-7161

Using the Noncanonical Metallo-Amino Acid [Cu(II)(2,2′-Bipyridin-5-yl)]-alanine to Study the Structures of Proteins. L. C. Tabares, D. T. Daniel, J. L. Vasquez-Ibar, C. Kouklovsky, V. Alezra, S. Un, J. Phys. Chem. Lett., 2023, 14, 3368-3375

Collective Total Synthesis of Mavacuran Alkaloids through Intermolecular 1,4-Addition of an Organolithium Reagent. A. Mauger, M. Jarret, A. Tap, R. Perrin, R. Guillot, C. Kouklovsky, V. Gandon, G. Vincent, Angew. Chem. Int. Ed., 2023, 62, e202302461

2022

Customized Reversible Stapling for Selective Delivery of Bioactive Peptides. Z. Zeng, J. Zhu, X. Deng, H. Chen, Y. Jin, E. Miclet, V. Alezra, Y. Wan, J. Am. Chem. Soc., 2022, 144, 23614-23621

Total synthesis of grayanane natural products. N. Fay, R. Blieck, C. Kouklovsky, A. De La Torre, Beilstein J. Org. Chem., 2022, 18, 1707-1719

Structure of the human heparan sulfate polymerase complex EXT1-EXT2. F. Leisico, J. Omeiri, C. Le Narvor, J. Beaudouin, M. Hons, D. Fenel, G. Schoehn, Y. Couté, D. Bonnaffé, R. Sadir, H. Lortat-Jacob, R. Wild, Nat Commun, 2022, 13, 7110

1,2-Boronate Rearrangement: An Efficient Tool for the Opening, Functionalization and Formation of Strained Cycles. R. Blieck, A. De La Torre, Eur. J. Org. Chem., 2022, e202200920

Diastereo- and Enantioselective Inverse-Electron-Demand Diels–Alder Cycloaddition between 2-Pyrones and Acyclic Enol Ethers. G. Huang, R. Guillot, C. Kouklovsky, B. Maryasin, A. De La Torre, Angew. Chem. Int. Ed., 2022, 61, e202208185

Gram-Scale Enantioselective Synthesis of (+)-Lucidumone. G. Huang, C. Kouklovsky, A. De La Torre, J. Am. Chem. Soc., 2022, 144, 17803-17807

Preparation of an advanced intermediate for the synthesis of leustroducsins and phoslactomycins by heterocycloaddition. A. Rousseau, G. Vincent, C. Kouklovsky, Beilstein J. Org. Chem., 2022, 18, 1385-1395

Total Synthesis of Ophiorrhine A, G and Ophiorrhiside E Featuring a Bioinspired Intramolecular Diels-Alder Cycloaddition. W. Cao, Y. Dou, C. Kouklovsky, G. Vincent, Angew. Chem. Int. Ed., 2022, 61, e202209135

Unbiased C3-Electrophilic Indoles: Triflic Acid Mediated C3-Regioselective Hydroarylation of N-H Indoles. N. Sabat, W. Zhou, V. Gandon, X. Guinchard, G. Vincent, Angewandte Chemie-International Edition, 2022, 61, e202204400

Cerium(IV)-Mediated Carbon-Carbon Bond Formation for the Synthesis of Spirodienone Lactams. P. Adler, V. Perez, L. Roupnel, A. Fadel, N. Rabasso, Eur. J. Org. Chem., 2022, e202200646

Electrochemical Benzylic C–H Functionalization with Isocyanides. S. Tang, R. Guillot, L. Grimaud, M. R. Vitale, G. Vincent, Org. Lett., 2022, 24, 2125-2130

Regioselective Reductive Opening of Benzylidene Acetals with Dichlorophenylborane/Triethylsilane: Previously Unreported Side Reactions and How to Prevent Them. J. Hénault, P. Quellier, M. Mock-Joubert, C. Le Narvor, A. Alix, D. Bonnaffé, J. Org. Chem., 2022, 87, 963-973

Discrimination of deletion to point cytokine mutants based on an array of cross-reactive receptors mimicking protein recognition by heparan sulfate. M. Genuia, L.-A. Garçon, Y. N. Sergeeva, B. Musnier, A. Buhot, M. Billon, E. Gout, R. Sadir, H. Lortat-Jacob, C. Le Narvor, D. Bonnaffé, T. Livache, Y. Hou, Analytical and Bioanalytical Chemistry, 2022, 414, 551-559

2021

Anticipate, Target and Characterize: MS²-anticipated C-glycosylflavones from Erythrococca anomala. T. Kouamé, T. Okpekon, N. F. Bony, S. Ferron, D. Bonnaffé, J. Vanheuverzwijn, Z. Zhou, V. Fontaine, A. D. N’Tamon, J.-F. Gallard, K. Leblanc, J.-C. Jullian, C. Miel, P. Champy, M. A. Beniddir, P. Le Pogam, Planta Medica International Open, 2021, 8, e131-e142

Enantioselective Au(I)-catalyzed dearomatization of 1-naphthols with allenamides through Tethered Counterion-Directed Catalysis. Y. Yu, Z. Zhang, A. Voituriez, N. Rabasso, G. Frison, A. Marinetti, X. Guinchard, Chem. Commun., 2021, 57, 10779-10782

Polymyxin B-inspired non-hemolytic tyrocidine A analogues with significantly enhanced activity against gram-negative bacteria: How cationicity impacts cell specificity and antibacterial mechanism. J. Zhu, C. Hu, Z. Zeng, X. Deng, L. Zeng, S. Xie, Y. Fang, Y. Jin, V. Alezra, Y. Wan, European Journal of Medicinal Chemistry, 2021, 221, 113488

Highly stereoselective aldol reactions by Memory of Chirality: synthesis of quaternary β-hydroxy α-amino acids. L. Roupnel, R. Guillot, D. Gori, B. Viswambharan, C. Kouklovsky, V. Alezra, Helv. Chim. Act., 2021, 104, e2100127

Synthesis of a Seco iso-Secologanin Aglycone Analogue of Interest toward Secoiridoids and Monoterpene Indole Alkaloids. H. Abou-Hamdan, R. Guillot, C. Kouklovsky, G. Vincent, J. Org. Chem., 2021, 86, 9244-9252

Inverse‐Electron‐Demand Diels–Alder Reactions of 2‐Pyrones: Bridged Lactones and Beyond. G. Huang, C. Kouklovsky, A. De La Torre, Chemistry - A European Journal, 2021, 27, 4760-4788

The chemistry of mavacurane alkaloids: a rich source of bis-indole alkaloids. A. Mauger, M. Jarret, C. Kouklovsky, E. Poupon, L. Evanno, G. Vincent, Nat. Prod. Rep., 2021, 38, 1852-1886

Bioinspired Early Divergent Oxidative Cyclizations toward Pleiocarpamine, Talbotine, and Strictamine. M. Jarret, H. Abou-Hamdan, C. Kouklovsky, E. Poupon, L. Evanno, G. Vincent, Org. Lett., 2021, 23, 1355-1360

Gramicidin-S-Inspired Cyclopeptidomimetics as Potent Membrane-Active Bactericidal Agents with Therapeutic Potential. C. Hu, Q. Wen, S. Huang, S. Xie, Y. Fang, Y. Jin, R. Campagne, V. Alezra, E. Miclet, J. Zhu, Y. Wan, ChemMedChem, 2021, 16, 368-376

Natural products originated from the oxidative coupling of tyrosine and tryptophan: biosynthesis and bioinspired synthesis. S. Tang, G. Vincent, Chem. Eur. J., 2021, 27, 2612-2622

2020

Development of Therapeutic Gramicidin S Analogues Bearing Plastic β,γ-Diamino Acids. Q. Guan, K. Chen, Q. Chen, J. Hu, K. Cheng, C. Hu, J. Zhu, Y. Jin, E. Miclet, V. Alezra, Y. Wan, ChemMedChem, 2020, 15, 1089-1100

The Pivotal Role of N-O bonds in the Synthesis of Natural Products: A mini-review. C. Kouklovsky, Vietnam J. Chem., 2020, 58, 20-28

Bioinspired Divergent Oxidative Cyclizations of Geissoschizine: Total Synthesis of (–)‐17‐nor‐Excelsinidine, (+)‐16‐epi‐Pleiocarpamine, (+)‐16‐Hydroxymethyl‐Pleiocarpamine and (+)‐Taberdivarine H. M. Jarret, A. Tap, V. Turpin, N. Denizot, C. Kouklovsky, E. Poupon, L. Evanno, G. Vincent, Eur. J. Org. Chem., 2020, 6340-6351

Bioinspired Divergent Oxidative Cyclization from Strictosidine and Vincoside Derivatives: Second Generation Total Synthesis of Cymoside and Access to an Original Hexacyclic‐Fused Furo[3,2‐b]indoline. Y. Dou, C. Kouklovsky, G. Vincent, Chem. Eur. J., 2020, 26, 17190-17194

Dearomatization Reactions of Indoles to Access 3D Indoline Structures. H. Abou-Hamdan, C. Kouklovsky, G. Vincent, Synlett, 2020, 31, 1775-1788

Electrochemical Reduction of α-Amino Allenylphosphonates to α-Amino Allylphosphonates. P. Adler, P. De Oliveira, N. Rabasso, Eur. J. Org. Chem., 2020, 3918-3925

Electrochemical dearomative dihydroxylation and hydroxycyclization of indoles. J. Wu, R. Guillot, C. Kouklovsky, G. Vincent, Adv. Synth. Catal., 2020, 362, 1712-1719

Electrochemical synthesis of 3a-bromofuranoindolines and 3a-bromopyrroloindolines mediated by MgBr2. J. Wu, H. Abou-Hamdan, R. Guillot, C. Kouklovsky, G. Vincent, Chem. Commun., 2020, 56, 1713-1716

Enantioselective Total Synthesis of Cymoside through a Bioinspired Oxidative Cyclization of a Strictosidine Derivative. Y. Dou, C. Kouklovsky, V. Gandon, G. Vincent, Angewandte Chemie-International Edition, 2020, 59, 1527-1531

2019

Unexpected dimerization of a tripeptide comprising a β,γ-diamino acid. Y. Wan, J.-P. Baltaze, C. Kouklovsky, E. Miclet, V. Alezra, Journal of Peptide Science, 2019, 25, e3143

Recent Advances in the Exploration of Therapeutic Analogues of Gramicidin S, an Old but Still Potent Antimicrobial Peptide. Q. Guan, S. Huang, Y. Jin, R. Campagne, V. Alezra, Y. Wan, J. Med. Chem., 2019, 62, 7603-7617

Copper-Catalyzed Phosphonylation/Trifluoromethylation of N-p-NO2-Benzoylacrylamides Coupled with Dearomatization and Denitration. J. Wu, D. Ma, G. Tang, Y. Zhao, Org. Lett., 2019, 21, 7674-7678

Dearomatization of 3‐Nitroindoles with Highly γ‐Functionalized Allenoates in Formal (3+2) Cycloadditions. L. Birbaum, L. Gillard, H. Gérard, H. Oulyadi, G. Vincent, X. Moreau, M. De Paolis, I. Chataigner, Chem. Eur. J., 2019, 25, 13688-13693

One-pot synthesis of a new generation of hybrid bisphosphonate polyoxometalate gold nanoparticles as antibiofilm agents. S. Tomane, E. López-Maya, S. Boujday, V. Humblot, J. Marrot, N. Rabasso, J. Castells-Gil, C. Sicard, A. Dolbecq, P. Mialane, A. Vallée, Nanoscale Adv., 2019, 1, 3400-3405

Bioinspired Oxidative Cyclization of the Geissoschizine Skeleton for Enantioselective Total Synthesis of Mavacuran Alkaloids. M. Jarret, V. Turpin, A. Tap, J.-F. Gallard, C. Kouklovsky, E. Poupon, G. Vincent, L. Evanno, Angewandte Chemie-International Edition, 2019, 58, 9861-9865

A Fused Hexacyclic Ring System: Diastereoselective Polycyclization of 2,4‐Dienals through an Interrupted iso‐Nazarov Reaction. A.-S. Marques, T. Duhail, J. Marrot, I. Chataigner, V. Coeffard, G. Vincent, X. Moreau, Angewandte Chemie-International Edition, 2019, 58, 9969-9973

Synthesis of 3,3-Spirocyclic 2-Phosphonoindolines via a Dearomative Addition of Phosphonyl Radicals to Indoles. D. Ryzhakov, M. Jarret, J.-P. Baltaze, R. Guillot, C. Kouklovsky, G. Vincent, Org. Lett., 2019, 21, 4986-4990

Substrate binding mode and catalytic mechanism of human heparan sulfate D-glucuronyl C5 epimerase. C. Debarnot, Y. R. Monneau, V. Roig-Zamboni, V. Delauzun, C. Le Narvor, E. Richard, J. Hénault, A. Goulet, F. Fadel, R. R. Vivès, B. Priem, D. Bonnaffé, H. Lortat-Jacob, Y. Bourne, Proc Natl Acad Sci USA, 2019, 116, 6760-6765

Electrochemical Dearomative 2,3-Difunctionalization of Indoles. J. Wu, Y. Dou, R. Guillot, C. Kouklovsky, G. Vincent, J. Am. Chem. Soc., 2019, 141, 2832-2837.

2018

Memory of Chirality in a Flow-Based System: Enantioselective Synthesis of Quaternary α-Amino Acids Using Flow Microreactors. A. Mambrini, D. Gori, C. Kouklovsky, H. Kim, J.-I. Yoshida, V. Alezra, European Journal of Organic Chemistry, 2018, 6754-6757

Oxidative coupling of enolates using memory of chirality: an original enantioselective synthesis of quaternary α-amino acid derivatives. A. Mambrini, D. Gori, R. Guillot, C. Kouklovsky, V. Alezra, Chem. Commun., 2018, 54, 12742-12745

Constrained Cyclic β,γ-Diamino Acids from Glutamic Acid: Synthesis of Both Diastereomers and Unexpected Kinetic Resolution. Y. Wan, N. Auberger, S. Thétiot-Laurent, F. Bouillère, A. Zulauf, J. He, S. Courtiol-Legourd, R. Guillot, C. Kouklovsky, S. Cote Des Combes, C. Pacaud, I. Devillers, V. Alezra, European Journal of Organic Chemistry, 2018, 329-340

N-Iodosuccinimide-Mediated Oxidative Coupling of Indoles and Phenols: A Synthetic Study toward the Benzofuroindoline Moiety of Bipleiophylline. N. Denizot, R. Guillot, C. Kouklovsky, G. Vincent, Synthesis, 2018, 50, 4823-4828

Combining Pure Shift And J-Edited Spectroscopies: A Strategy For Extracting Chemical Shifts And Scalar Couplings From Highly Crowded Proton Spectra Of Oligomeric Saccharides. D. Pitoux, Z. Hu, B. Plainchont, D. Merlet, J. Farjon, D. Bonnaffe, N. Giraud, Magn. Reson. Chem., 2018, 56, 954-962

Diastereoselective Synthesis of an Advanced Intermediate of Thapsigargin and Other 6,12-Guaianolides Using a RCEYM Strategy. M. Jouanneau, K. R. Bonepally, A. Jeuken, A. Tap, R. Guillot, J. Ardisson, J.-P. Férézou, J. Prunet, Org. Lett., 2018, 20, 2176-2180

Bioinspired Oxidative Cyclization of the Geissoschizine Skeleton for the Total Synthesis of (‐)‐17‐nor‐Excelsinidine. M. Jarret, A. Tap, C. Kouklovsky, E. Poupon, L. Evanno, G. Vincent, Angewandte Chemie-International Edition, 2018, 57, 12294-12298

Dearomative Diallylation of N-Acylindoles Mediated by FeCl3. J. Wu, R. K. Nandi, R. Guillot, C. Kouklovsky, G. Vincent, Org. Lett., 2018, 20, 1845-1848

Base mediated fragmentation of bicyclic dihydro-3,6-oxazines: transformation of nitroso Diels-Alder cycloadducts. R. Campagne, F. Schäkel, R. Guillot, V. Alezra, C. Kouklovsky, Org. Lett., 2018, 20, 1884-1887

β,γ-Diamino acids as building blocks for new analogues of Gramicidin S: synthesis and biological activity. Y. Wan, A. Stanovych, D. Gori, S. Zirah, C. Kouklovsky, V. Alezra, Eur. J. Med. Chem., 2018, 149, 122-128.

Divergent Oxidative Couplings between Indoles and 2,3-Dihydroxybenzoic Acid Derivatives for the Biomimetic Synthesis of Voacalgine A and Bipleiophylline. N. Denizot, D. Lachkar, C. Kouklovsky, E. Poupon, L. Evanno, G. Vincent, Synthesis, 2018, 50, 4229-4242

In Situ Generation of Cyclopentadienol Intermediates from 2,4-Dienals. Application to the Synthesis of Spirooxindoles via a Domino Polycyclization. A.-S. Marques, J. Marrot, I. Chataigner, V. Coeffard, G. Vincent, X. Moreau, Org. Lett., 2018, 20, 792-795

Triflic acid as an efficient Brønsted acid promoter for the Umpolung of N-Ac indoles in hydroarylation reactions. R. K. Nandi, A. Perez-Luna, D. Gori, R. Beaud, R. Guillot, C. Kouklovsky, V. Gandon, G. Vincent, Adv. Synth. Catal., 2018, 360, 161–172

Interfering peptides targeting protein–protein interactions: the next generation of drugs? H. Bruzzoni-Giovanelli, V. Alezra, N. Wolff, C.-Z. Dong, P. Tuffery, A. Rebollo, Drug Discovery Today, 2018, 23, 272-285

2017

A Versatile Electronic Tongue Based on Surface Plasmon Resonance Imaging and Cross-Reactive Sensor Arrays-A Mini-Review. L.-A. Garçon, M. Genua, Y.-J. Hou, R. Calemczuk, T. Livache, M. Billon, C. Le Narvor, D. Bonnaffé, H. Lortat-Jacob, Y. Hou, Sensors, 2017, 17, 1046

Radical-Mediated Dearomatization of Indoles with Sulfinate Reagents for the Synthesis of Fluorinated Spirocyclic Indolines. D. Ryzhakov, M. Jarret, R. Guillot, C. Kouklovsky, G. Vincent, Org. Lett, 2017, 19, 6336-6339

Expedient Approach to α,β-Unsaturated δ-Lactones via a Catalytic Asymmetric [2+2] Cycloaddition. C. Kouklovsky, A. Rousseau, M. Buchotte, R. Guillot, G. Vincent, Eur. J. Org. Chem., 2017, 6804-6810

Synthesis of N-Sulfonyl Ynamido-Phosphonates: Valuable Partners for Cycloadditions. V. Perez, A. Fadel, N. Rabasso, Synthesis, 2017, 49, 4035-4044

Frozen Chirality of Tertiary Aromatic Amides :Access to Enantioenriched Tertiary alpha-Amino Acid or Amino Alcohol without Chiral Reagent. T. T. Mai, B. Viswambharan, D. Gori, R. Guillot, J.-V. Naubron, C. Kouklovsky, V. Alezra, Chem. Eur. J., 2017, 23, 5787-5798

Revealing the Electrophilicity of N-Ac Indoles with FeCl3: a mechanistic study. R. Beaud, R. K. Nandi, A. Perez-Luna, R. Guillot, D. Gori, C. Kouklovsky, N. E. Ghermani, V. Gandon, G. Vincent, Chem. Commun., 2017, 53, 5834 - 5837

Evaluation of an NIS-Mediated Oxidative Cyclisation of Phenol-Containing N-Acyltryptamine Precursors towards Phalarine: Synthesis of 4′,5′-Dihydrospiro[indole-3,6′-[1,3]oxazine]s. T. Tomakinian, H. Abou Hamdan, N. Denizot, R. Guillot, J.-P. Baltaze, C. Kouklovsky, G. Vincent, Eur. J. Org. Chem., 2017, 19, 2757–2763

Unified biomimetic assembly of voacalgine A and bipleiophylline via divergent oxidative couplings. D. Lachkar, N. Denizot, G. Bernadat, K. Ahamada, M. A. Beniddir, V. Dumontet, J.-F. Gallard, R. Guillot, K. Leblanc, E. O. N'Nang, V. Turpin, C. Kouklovsky, E. Poupon, L. Evanno, G. Vincent, Nature Chemistry, 2017, 9, 793-798

From acyclic to cyclic α-amino vinylphosphonates by using ring-closing metathesis. P. Adler, A. Fadel, J. Prunet, N. Rabasso, Org. Biomol. Chem., 2017, 15, 387-395

2016

CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge. K. K. Arien, F. Baleux, D. Desjardins, F. Porrot, Y.-M. Coic, J. Michiels, K. Bouchemal, D. Bonnaffe, T. Bruel, O. Schwartz, R. Le Grand, G. Vanham, N. Dereuddre-Bosquet, H. Lortat-Jacob, SCIENTIFIC REPORTS, 2016, 6

Iron-Mediated Domino Interrupted Iso-Nazarov/Dearomative (3 + 2)-Cycloaddition of Electrophilic Indoles. A.-S. Marques, V. Coeffard, I. Chataigner, G. Vincent, X. Moreau, Org. Lett., 2016, 18, 5296-5299

Recent Progress in Memory Of Chirality (MOC): An Advanced Chiral Pool. V. Alezra, T. Kawabata, Synthesis, 2016, 48, 2997-3016

Efficient synthesis of both diastereomers of β,γ-diamino acids from phenylalanine and tryptophan. N. Auberger, A. Stanovych, S. Thétiot-Laurent, R. Guillot, C. Kouklovsky, S. Cote Des Combes, C. Pacaud, I. Devillers, V. Alezra, Amino Acids, 2016, 48(9), 2237-2242

Synthesis of 3,3-Spiroindolines via FeCl3-Mediated Cyclization of Aryl- or Alkene-Containing 3-Substituted N-Ac Indoles. R. K. Nandi, R. Guillot, C. Kouklovsky, G. Vincent, Org. Lett., 2016, 18, 1716-1719

Synthesis of benzofuro[3,2-b]indoline amines via deamination-interrupted Fischer indolization and their unexpected reactivity towards nucleophiles. T. Tomakinian, R. Guillot, C. Kouklovsky, G. Vincent, Chem. Commun., 2016, 52, 5443-5446

Intermolecular dearomative C2-arylation of N-Ac indoles activated by FeCl3. R. K. Nandi, F. Ratsch, R. Beaud, R. Guillot, C. Kouklovsky, G. Vincent, Chem. Commun., 2016, 52, 5328-5331

Synthesis of 5-Phosphonoisoxazoline N-Oxides by Selective O-Alkylation of Nitronate Anions. V. Perez, N. Rabasso, A. Fadel, Eur. J. Org. Chem., 2016, 320-324

2015

Magnetic field dependence of spatial frequency encoding NMR as probed on an oligosaccharide. D. Pitoux, Z. Hu, B. Plainchont, D. Merlet, J. Farjon, D. Bonnaffe, N. Giraud, Magn. Reson. Chem., 2015, 53, 836-844

Connecting Tyrosine and Tryptophan Units of Diazonamide A and Azonazine by a Diastereodivergent Arylative Dearomatization. N. Denizot, R. Guillot, C. Kouklovsky, G. Vincent, Chem. Eur. J., 2015, 21, 18953-18956

Synthesis of 3-arylated indolines from dearomatization of indoles. N. Denizot, T. Tomakinian, R. Beaud, C. Kouklovsky, G. Vincent, Tetrahedron Lett., 2015, 56, 4413-4429

Investigation of the Synthesis of Benzofuroindolines from N-Hydroxyindoles: An O-Arylation/[3,3]-Sigmatropic Rearrangement Sequence. T. Tomakinian, C. Kouklovsky, G. Vincent, Synlett, 2015, 1269-1275

The quest of an oxidative coupling of phenols and indoles towards benzofuroindolines: a two stage approach. R. Beaud, T. Tomakinian, N. Denizot, A. Pouilhès, C. Kouklovsky, G. Vincent, Synlett, 2015, 432-435

Mild Cleavage of N–O Bond of 3,6-Dihydro-1,2-oxazines by Condensation of Aldehydes in Aqueous Media. G. Galvani, R. Lett, C. Kouklovsky, Synlett, 2015, 26, 1340-1344

Fully Resolved NMR Correlation Spectroscopy. D. Pitoux, B. Plainchont, D. Merlet, Z. Hu, D. Bonnaffé, J. Farjon, N. Giraud, Chemistry - A European Journal, 2015, 21, 9044-9047

Cerium(iv) ammonium nitrate mediated 5-endo-dig cyclization of α-amino allenylphosphonates to spirodienones. P. Adler, A. Fadel, N. Rabasso, Chem. Commun., 2015, 51, 3612-3615

2014

Landscapes of taste by a novel electronic tongue for the analysis of complex mixtures. L.-A. Garçon, Y. Hou, M. Genua, A. Buhot, R. Calemczuk, D. Bonnaffé, Y. Hou, T. Livache, Sensor Letters, 2014, 12, 1059-1064

Oxidative degradation of amino acids and aminophosphonic acids by 2,2-bipyridine complexes of Copper(II). J. S. Pap, N. El Bakkali-Tahéri, A. Fadel, S. Goger, D. Bogath, M. Molnar, M. Giorgi, G. Speier, A. J. Simaan, J. Kaizer, Eur. J. Inorg. Chem, 2014, 2829–2838

From Chitin to Bioactive Chitooligosaccharides and Conjugates: Access to Lipochitooligosaccharides and the TMG-chitotriomycin. G. Despras, A. Alix, D. Urban, B. Vauzeilles, J.-M. Beau, Angew. Chem. Int. Ed., 2014, 53, 11912-11916

Strategies for the synthesis of α- and β-amino vinylphosphonate. P. Adler, A. Fadel, N. Rabasso, Tetrahedron, 2014, 70, 4437-4456

Cyclopropanation of 1,2-dibromoethylphosphonate: a synthesis of β-aminocyclopropylphosphonic acid and derivatives. N. Rabasso, A. Fadel, Tetrahedron Lett., 2014, 55, 6068-6071

Repairing the Thiol-Ene Coupling Reaction. G. Povie, A.-T. Tran, D. Bonnaffe, J. Habegger, Z. Hu, C. Le Narvor, P. Renaud, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53, 3894-3898

Characterization of Glycosaminoglycan (GAG) Sulfatases from the Human Gut Symbiont Bacteroides thetaiotaomicron Reveals the First GAG-specific Bacterial Endosulfatase. J. E. Ulmer, E. M. Vilen, R. B. Namburi, A. Benjdia, J. Beneteau, A. Malleron, D. Bonnaffe, P.-A. Driguez, K. Descroix, G. Lassalle, C. Le Narvor, C. Sandstrom, D. Spillmann, O. Berteau, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289, 24289-24303

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis. Y. Hou, M. Genua, L.-A. Garcon, A. Buhot, R. Calemczuk, D. Bonnaffe, H. Lortat-Jacob, T. Livache, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2014

SPR imaging based electronic tongue via landscape images for complex mixture analysis. M. Genua, L.-A. Garcon, V. Mounier, H. Wehry, A. Buhot, M. Billon, R. Calemczuk, D. Bonnaffe, Y. Hou, T. Livache, TALANTA, 2014, 130, 49-54

Substrate Control in Enantioselective and Diastereoselective Aldol Reaction by Memory of Chirality: A Rapid Access to Enantiopure β-Hydroxy Quaternary α-Amino Acids. B. Viswambharan, D. Gori, R. Guillot, C. Kouklovsky, V. Alezra, Org. Lett., 2014, 16, 788-791

Regioselective Hydroarylation Reactions of C3 Electrophilic N-Acetylindoles Activated by FeCl3: An Entry to 3-(Hetero)arylindolines. R. Beaud, R. Guillot, C. Kouklovsky, G. Vincent, Chem. Eur. J., 2014, 20, 7492-7500

Direct Oxidative Coupling of N-Acetyl Indoles and Phenols for the Synthesis of Benzofuroindolines Related to Phalarine. T. Tomakinian, R. Guillot, C. Kouklovsky, G. Vincent, Angew. Chem. Int. Ed., 2014, 53, 11881-11885

Bioinspired Direct Access to Benzofuroindolines by Oxidative [3 + 2] Annulation of Phenols and Indoles. N. Denizot, A. Pouilhès, M. Cucca, R. Beaud, R. Guillot, C. Kouklovsky, G. Vincent, Org. Lett., 2014, 16, 5752-5755

β,γ-Diamino acid: an original building block for hybrid α/γ-peptide synthesis with extra hydrogen bond donating group. A. Stanovych, R. Guillot, C. Kouklovsky, E. Miclet, V. Alezra, Amino Acids, 2014, 46, 2753-2757

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