Sandrine Deloisy
Sandrine Deloisy studied chemistry at the University of Paris-Sud (Orsay) and obtained her PhD in 1994. Her doctoral research on the synthesis of new fluoroquinolones as potential antibacterial agents was carried out at the Institut de Chimie des Substances Naturelles (ICSN, Gif-sur-Yvette) under the supervision of Dr. Gabor Lukacs. Supported by the Alexander von Humboldt Foundation, she spent two years in Mainz (Germany) in the group of Pr. Horst Kunz where she developed the use of carbohydrates as chiral auxiliaries. Coming back in France, she obtained a teaching position in the IUT of Orsay as ATER then as Maître de Conférences. In 1997, she joined Dr. Robert Bloch's group at the Institut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO) where she studied the application of furan Diels-Alder chemistry on solid support and developed the chemistry of 7-oxanorbornadienes. In 2009, she turned her interest in the synthesis of organosilicon compounds with the collaboration of Dr. Luis Blanco. Since 2014, she works in the group of Pr. David J. Aitken on silyloxymalononitrile derivatives as umpolung reagents for the development of the one-pot multicomponent MAC Methodology.
Keywords: organic chemistry, multi-step synthesis, methodology, Masked Acyl Cyanide reaction, oxyhomologation of amino adehydes, organosilicon chemistry.
Recent publications :
High anti Diastereoselectivity in a Tandem Oxyhomologation−Coupling Protocol for the Preparation of Amides and Peptides Incorporating α‑Hydroxy β‑Amino Acids. X. He, R. Guillot, S. Deloisy, D. J. Aitken, Organic Letters, 2024, 26, 2207-2211
A case study of the MAC (Masked Acyl Cyanide) oxyhomologation of N,N-dibenzyl-L-phenylalaninal with anti diastereoselectivity: preparation of (2S,3S)-allophenylnorstatin esters. X. He, M. Buchotte, R. Guillot, S. Deloisy, D. J. Aitken, Organic & Biomolecular Chemistry, 2022, 20, 1769-1781
Reversal of Diastereoselectivity in a Masked Acyl Cyanide (MAC) Reaction: Synthesis of Protected erythro-β-Hydroxyaspartate Derivatives. M. Esgulian, M. Buchotte, R. Guillot, S. Deloisy, D. J. Aitken, Org. Lett., 2019, 21, 2378-2382
Studies on cyclization reactions of 3-amino-2,4-dihydroxybutanoic acid derivatives. M. Esgulian, V. Belot, R. Guillot, S. Deloisy, D. J. Aitken, Org. Biomol. Chem., 2017, 15, 1453-1462