Institut de Chimie Moléculaire et des Matériaux d'Orsay

Martial Toffano

Chargé de Recherche
Bât. 670, bureau 2220 – LCM – ICMMO - UMR 8182
Université Paris-Saclay
Bâtiment 670
17-19 Avenue des Sciences
91400 Orsay

+33 1 69 15 47 38

Fatty and aromatic acids as acyl donors in enzymatic kinetic resolution of phenylethanol and 1-phenylpropan-2-ol. F. Z. Smaine, M. Merabet-Khelassi, S. Zeror, E. Kolodziej, M. Toffano, L. Aribi-Zouioueche, Monatshefte für Chemie - Chemical Monthly, 2024

2-Hydroxymethyl-18-crown-6 as an efficient organocatalyst for a-aminophosphonates synthesized under eco-friendly conditions, DFT, molecular docking and ADME/T studies. S. Guezane-Lakoud, M. Ferrah, M. Merabet-Khelassi, N. Touil, M. Toffano, L. Aribi-Zouioueche, Journal of Biomolecular Structure and Dynamics, 2023, 0739-1102

Full factorial optimization of α-aminophosphonates synthesis using diphenylphosphinic acid as efficient organocatalyst. M. Ferrah, S. Guezane-Lakoud, H. Bendjeffal, R. Aissa, M. Merabet-Khelassi, M. Toffano, L. Aribi-Zouioueche, Reaction Kinetics, Mechanisms and Catalysis, 2023, 136, 165-182

Practical access to (S)-heterocyclic aromatic acetates via CAL-B/Na2CO3-deacylation and Mitsunobu reaction protocol. N. Braïa, M. Merabet-Khelasi, M. Toffano, L. Aribi-Zouioueche, Biocatalysis and Biotransformation, 2023, 41, 261-269

Access to valuable building blocks by regio-and enantioselective ring-opening of itaconic anhydride using lipase catalysis. N. Braia, M. Merabet-Khelassi, M. Toffano, R. Guillot, L. Aribi-Zouioueche, Org. Biomol. Chem., 2022, 20, 2693-2703

New promising generation of phosphates α-aminophosphonates: Design, Synthesis, In-vitro biological evaluation and Computational study. R. Aissa, S. Guezane-Lakoud, L. Gali, M. Toffano, A. Ignaczak, M. Adamiak, M. Merabet-Khelassi, R. Guillot, L. Aribi-Zouioueche, Journal of Molecular Structure, 2022, 1247, 131336

Two Approaches for CAL-B-Catalyzed Enantioselective Deacylation of a Set of α-Phenyl Ethyl Esters: Organic Solvent with Sodium Carbonate and Micro-aqueous Medium. S. Razi, S. Zeror, M. Merabet-Khelassi, E. Kolodziej, M. Toffano, L. Aribi-Zouioueche, Catalysis Letters, 2021, 151, 2603-2611

Fiaud’s Acid, a novel organocatalyst for diastereoselective bis α-aminophosphonates synthesis with in-vitro biological evaluation of antifungal, antioxidant and enzymes inhibition potential. R. Aissa, S. Guezane-Lakoud, M. Toffano, L. Gali, L. Aribi-Zouioueche, Bioorganic & Medicinal Chemistry Letters, 2021, 41, 128000

Bifunctional N-Heterocylic Carbene-Catalyzed Highly Enantioselective Trans-Cyclopentannulation of Enals and Enones via Homoenolate. Z. Jiang, M. Toffano, G. Vo-Thanh, C. Bournaud, ChemCatChem, 2021, 13, 712-717

Enantioselective Hydrophosphonylation of N-Boc Imines using Chiral Guanidine–Thiourea Catalysts. L. Chassillan, Y. Yamashita, W.-J. Yoo, M. Toffano, R. Guillot, S. Kobayashi, G. Vo-Thanh, Org. Biomol. Chem., 2021, 19, 10560-10564

Auto Tandem Catalysis: Asymmetric Vinylogous Cycloaddition / Kinetic Resolution Sequence for the Enantioselective Synthesis of Spiro-Dihydropyranone from Benzylidene Meldrum’s Acid. M. Toffano, R. Guillot, C. Bournaud, J.-F. Brière, G. Vo-Thanh, Advanced Synthesis & Catalysis, 2021, 363, 4452-4458

Alkylidene Meldrum’s Acids as Novel Platforms for the Vinylogous Synthesis of Dihydropyranones. G. Vo-Thanh, S. Wittmann, T. Martzel, C.-T. Pham Truong, M. Toffano, S. Oudeyer, R. Guillot, C. Bournaud, V. Gandon, J.-F. Brière, Angewandte Chemie International Edition, 2021, 60, 11110-11114

Novel One-Pot Access to Diastereoisomeric Tertiary Phospholanes Oxides by Using Enantiomerically Pure Phospholane Oxides Under Catalyst-Free Conditions. S. G. Lakoud, R. Aissa, R. Guillot, M. Toffano, L. Aribi-Zouioueche, ChemistrySelect, 2020, 5, 379-383

Chiral catalysts derived from biomass: design, synthesis and applications in asymmetric catalysis. T. T. D. Ngo, K.-D. Huynh, H. Ibrahim, T. H. Nguyen, C. Bournaud, M. Toffano, G. Vo-Thanh, Vietnam Journal of Chem, 2019, 57, 670-680

Diastereoselective synthesis of novel bis(α-aminophosphonates) by lipase catalytic promiscuity. R. Aissa, S. Guezane Lakoud, E. Kolodziej, M. Toffano, L. Aribi-Zouioueche, New. J. Chem., 2019, 43, 8153-8159

Photoredox-initiated 1,2-Difunctionalization of Alkenes with N-Chloro S-Fluoroalkyl Sulfoximines. A. Prieto, P. Diter, M. Toffano, J. Hannedouche, E. Magnier, Adv. Synth. Catal., 2019, 361, 436-440

Facile Preparation of Vinyl S-Trifluoromethyl NH Aryl Sulfoximines. A.-L. Barthelemy, A. Prieto, P. Diter, J. Hannedouche, M. Toffano, E. Anselmi, E. Magnier, Eur. J. Org. Chem., 2018, 3764-3770

Novel Class of Reversible Chiral Ionic Liquids Derived from Natural Amino Acids: Synthesis and Characterization. L. Bouchardy, V. Rodriguez-Ruiz, F.-D. Boyer, C. Bournaud, M. Toffano, P. Judeinstein, G. Vo-Thanh, ChemistrySelect, 2018, 3, 958-962

Promiscuous lipase catalyzed a new P–C bond formation: Green and efficient protocol for one‐pot synthesis of α‐aminophosphonates. S. Guezane‐lakoud, M. Toffano, L. Aribi‐zouioueche, Heteroatom Chemistry, 2017, 28, e21408

S-Trifluoromethyl Sulfoximine as a Directing Group in Ortho-Lithiation Reaction toward Structural Complexity. T.-N. Le, P. Diter, B. Pégot, C. Bournaud, M. Toffano, R. Guillot, G. Vo-Thanh, E. Magnier, Org. Lett., 2016, 18, 5102-5105

Organocatalyzed [4+2] Annulation of All-Carbon Tetrasubstituted Alkenes with Allenoates: Synthesis of Highly Functionalized 2H- and 4H-Pyran Derivatives. T.-T.-D. Ngo, K. Kishi, M. Sako, M. Shigenobu, C. Bournaud, M. Toffano, R. Guillot, J.-P. Baltaze, S. Takizawa, H. Sasai, G. Vo-Thanh, ChemistrySelect, 2016, 1, 5414-5420

Biosourced Ligands from Isosorbide for the Ethylation of Aldehydes or Alkynylation of Imines. K.-D. Huynh, H. Ibrahim, L. Bouchardy, C. Bournaud, E. Kolodziej, M. Toffano, G. Vo-Thanh, Asian Journal of Organic Chemistry, 2016, 1242-1246

Phosphine–Thiourea-Organocatalyzed Asymmetric C−N and C−S Bond Formation Reactions. T.-T.-D. Ngo, T.-H. Nguyen, C. Bournaud, R. Guillot, M. Toffano, G. Vo-Thanh, Asian Journal of Organic Chemistry, 2016, Volume 5, Issue 7, 895–899

Functionalized S-perfluorinated sulfoximines: preparation and evaluation in catalytic process. T.-N. Le, P. Diter, B. Pégot, C. Bournaud, M. Toffano, R. Guillot, G. Vo-Thanh, Y. Yagupolskii, E. Magnier, Journal of Florine Chemistry, 2015, 179, 179-187

P-Aryl-Diphenylphospholanes and their Phospholanium Salts as Efficient Monodentate Ligands for Asymmetric Rhodium-Catalyzed Hydrogenation. C. Dobrota, J.-C. Fiaud, M. Toffano, ChemCatChem, 2015, 7, 144-148

Synthesis and Characterization of New Chiral Azolinium Salts, Precursors to N-Heterocyclic Carbenes, Derived from l-Proline. A. Thomasset, L. Bouchardy, C. Bournaud, R. Guillot, M. Toffano, G. Vo-Thanh, Synthesis, 2014, 46, 242-250

Synthesis of chiral thiourea–phosphine organocatalysts derived from l-proline. T.-H. Nguyen, M. Toffano, C. Bournaud, G. Vo-Thanh, Tetrahedron Letters, 2014, 55, 6377-6380

First Isolation of Enantiopure Perfluoroalkylated Sulfilimines and Sulfoximines. T.-N. Le, E. Kolodziej, P. Diter, B. Pégot, C. Bournaud, M. Toffano, R. Guillot, G. Vo-Thanh, E. Magnier, CHIMIA International Journal for Chemistry, 2014, 68, 410-413