Institut de Chimie Moléculaire et des Matériaux d'Orsay

Denis Merlet

Bât. 410, bureau 20 – LRMN – ICMMO
Université Paris-Saclay
Rue du doyen Georges Poitou
91405 Orsay Cedex

+33 1 69 15 74 32

Curriculum Vitae


* Doctorat , Université Paris VII - Denis Diderot , Orsay 1998

* Post-doc (1998-99): Prof. J.W. EMSLEY à l'Université de Southampton. (Bourse Lavoisier ).

* Maître de Conférences, Université Paris Sud XI, Orsay 1999

* HDR, Université Paris Sud XI Orsay 2007

* Professeur des Universités, Université Paris Sud XI Orsay 2008



Dernière publications


Multinuclear NMR in polypeptide liquid crystals: Three fertile decades of methodological developments and analytical challenges. P. Lesot, C. Aroulanda, P. Berdague, A. Meddour, D. Merlet, J. Farjon, N. Giraud, O. Lafon, Progress in Nuclear Magnetic Resonance Spectroscopy, 2019, Ahead of Print

The use of residual dipolar couplings for conformational analysis of non-steroidal anti-inflammatory drugs dissolved in weakly ordering media. M. E. Di Pietro, G. Celebre, R. A. Salvino, C. Aroulanda, D. Merlet, G. De Luca, Liq. Cryst, 2018

Combining Pure Shift And J-Edited Spectroscopies: A Strategy For Extracting Chemical Shifts And Scalar Couplings From Highly Crowded Proton Spectra Of Oligomeric Saccharides. D. Pitoux, Z. Hu, B. Plainchont, D. Merlet, J. Farjon, D. Bonnaffe, N. Giraud, Magnetic Resonance in Chemistry, 2018, 56

Assessing the stable conformations of ibuprofen in solution by means of Residual Dipolar Couplings. M. E. Di Pietro, G. Celebre, C. Aroulanda, D. Merlet, G. De Luca, European Journal of Pharmaceutical Sciences, 2017, 106, 113-121

Synthesis, characterization and structural study of mercury(II) complexes with fluoroalkylthiocarbamates. I. Chniti, M. A. K. Sanhoury, H. Maouati, R. Guillot, D. Merlet, I. Chehidi, Journal of Molecular Structure, 2017, 1128, 64-69

Achieving High Resolution And Optimizing Sensitivity In Spatially Frequency Encoding NMR Spectroscopy: From Theory To Practice. B. Plainchont, D. Pitoux, G. Hamdoun, J.-M. Ouvrard, D. Merlet, J. Farjon, N. Giraud, Physical Chemistry Chemical Physics, 2016, 18, 22827-22839

The conformational behaviour of naproxen and flurbiprofen in solution by NMR spectroscopy. M. E. Di Pietro, C. Aroulanda, G. Celebre, D. Merlet, G. De Luca, New Journal of Chemistry, 2015, 39, 9086-9097

On the Content of Conformational and Orientational Information from Dipolar Couplings in two Anisotropic Media with a Very Different Degree of Ordering : Thermotropic versus Lyotropic Liquid Crystals. M. E. Di Pietro, G. De Luca, G. Celebre, D. Merlet, C. Aroulanda, Molecular Crystals and Liquid Crystals, 2015, 614, 39-53

Magnetic field dependence of spatial frequency encoding NMR as probed on an oligosaccharide. D. Pitoux, Z. Hu, B. Plainchont, D. Merlet, J. Farjon, D. Bonnaffe, N. Giraud, MAGNETIC RESONANCE IN CHEMISTRY, 2015, 53, 836-844

Fine Tuning of β-Peptide Foldamers: a Single Atom Replacement Holds Back the Switch from an 8-Helix to a 12-Helix. A. Altmayer-Henzien, V. Declerck, J. Farjon, D. Merlet, R. Guillot, D. J. Aitken, Angewandte Chemie International Edition, 2015, 54, 10807-10810

A comprehensive NMR methodology to assess the composition of biobased and biodegradable polymers in contact with food. A. Gratia, D. Merlet, V. Ducruet, C. Lyathaud, Analytica Chimica Acta, 2015, 853, 477-485

Fully Resolved NMR Correlation Spectroscopy. D. Pitoux, B. Plainchont, D. Merlet, Z. Hu, D. Bonnaffe, J. Farjon, N. Giraud, Chemistry - A European Journal, 2015, 21, 9044-9047

Pushing the limits of signal resolution to make coupling measurement easier. J. E. H. Pucheta, D. Pitoux, C. M. Grison, S. Robin, D. Merlet, D. J. Aitken, N. Giraud, J. Farjon, Chem Commun, 2015, 51, 7939-7942

Synthesis and conformational study of new S-polyfluoroalkyl dithiocarbamates. I. Chniti, M. A. K. Sanhoury, D. Merlet, I. Chehidi, Journal of Fluorine Chemistry, 2014, 168, 223-229

Conformational Investigation in Solution of a Fluorinated Anti-inflammatory Drug by NMR Spectroscopy in Weakly Ordering Media. M. E. Di Pietro, C. Aroulanda, D. Merlet, G. Celebre, G. De Luca, Journal of Physical Chemistry B, 2014, 118, 9007-9016

Les publis de Laurent

Novel N-substituted 5-phosphate-D-arabinonamide derivatives as strong inhibitors of phosphoglucose isomerases: synthesis, structure-activity relationship and crystallographic studies. L. Ahmad, S. Plancqueel, N. Lazar, H. Korri-Youssoufi, I. Li De La Sierra-Gallay, H. Van Tilbeurgh, L. Salmon, Bioorg. Chem., 2020, 102, 104048

Calibration of the dianionic phosphate group: Validation on the recognition site of the homodimeric enzyme phosphoglucose isomerase. M. Devillers, J.-P. Piquemal, L. Salmon, N. Gresh, J. Comput. Chem., 2020, 41, 839-854

Electrochemical detection of the human cancer biomarker ‘autocrine motility factor-phosphoglucose isomerase’ based on a biosensor formed with a monosaccharidic inhibitor. L. Ahmad, L. Salmon, H. Korri-Youssoufi, Sens. Actuators B Chem., 2019, 299, 126933

Bisphosphonate inhibitors of mammalian glycolytic aldolase. P. Heron, M. Abellán-Flos, L. Salmon, J. Sygusch, J. Med. Chem., 2018, 61, 10558-10572

Spin-crossover nanoparticles and nanocomposite materials. L. Salmon, L. Catala, Comptes Rendus Chimie, 2018, 10.1016/j.crci.2018.07.009

Crystal Structure of Phosphomannose Isomerase from Candida albicans Complexed with 5‐Phospho‐D‐Arabinonhydrazide. L. Ahmad, S. Plancqueel, V. Dubosclard, N. Lazar, W. Ghattas, I. Li De La Sierra‐gallay, H. Van Tilbeurgh, L. Salmon, FEBS Lett., 2018, 592, 1667-1680

Carbohydrate-based electrochemical biosensor for detection of a cancer biomarker in human plasma. M. Devillers, L. Ahmad, H. Korri-Youssoufi, L. Salmon, Biosens. Bioelectron., 2017, 96, 178-185

Complexes of a Zn-metalloenzyme binding site with hydroxamate-containing ligands. A case for detailed benchmarkings of polarizable molecular mechanics/dynamics potentials when the experimental binding structure is unknown. N. Gresh, D. Perahia, B. De Courcy, J. Foret, C. Roux, L. El-Khoury, J.-P. Piquemal, L. Salmon, J. Comput. Chem., 2016, 37, 2770-2782

Structural Basis for Competitive Inhibition of 3,4-Dihydroxy-2-Butanone-4-Phosphate Synthase from Vibrio cholerae. Z. Islam, A. Kumar, S. Singh, L. Salmon, S. Karthikeyan, J. Biol. Chem., 2015, 290, 11293-11308