Christine Le narvor
Research Interests
Development chemical or enzymatical (glyco)biology approaches to understand, at the molecular level, biological processes in which carbohydrates are involved.
CV
PhD: Université Paris Sud, Orsay (Prof. Serge David /Dr Claudine Augé)
Habilitation à Diriger des Recherches : Université Paris Sud, Orsay
Post-doc: Scripps Institute, La Jolla, USA (Prof Chi Huey Wong)
Current Situation: CNRS Associate Scientist (CRHC), ICMMO, Université Paris Sud, Orsay
Recent Publications
Functional and structural insights into human N-deacetylase/N-sulfotransferase activities. S. D. Vallet, T. Annaval, R. R. Vivès, J. Hénault, C. Le Narvor, D. Bonnaffé, B. Priem, R. Wild, H. Lortat-Jacob, Proteoglycan Research, 2023, 1, e8
Structure of the human heparan sulfate polymerase complex EXT1-EXT2. F. Leisico, J. Omeiri, C. Le Narvor, J. Beaudouin, M. Hons, D. Fenel, G. Schoehn, Y. Couté, D. Bonnaffé, R. Sadir, H. Lortat-Jacob, R. Wild, Nat Commun, 2022, 13, 7110
Regioselective Reductive Opening of Benzylidene Acetals with Dichlorophenylborane/Triethylsilane: Previously Unreported Side Reactions and How to Prevent Them. J. Hénault, P. Quellier, M. Mock-Joubert, C. Le Narvor, A. Alix, D. Bonnaffé, J. Org. Chem., 2022, 87, 963-973
Discrimination of deletion to point cytokine mutants based on an array of cross-reactive receptors mimicking protein recognition by heparan sulfate. M. Genuia, L.-A. Garçon, Y. N. Sergeeva, B. Musnier, A. Buhot, M. Billon, E. Gout, R. Sadir, H. Lortat-Jacob, C. Le Narvor, D. Bonnaffé, T. Livache, Y. Hou, Analytical and Bioanalytical Chemistry, 2022, 414, 551-559
Substrate binding mode and catalytic mechanism of human heparan sulfate D-glucuronyl C5 epimerase. C. Debarnot, Y. R. Monneau, V. Roig-Zamboni, V. Delauzun, C. Le Narvor, E. Richard, J. Hénault, A. Goulet, F. Fadel, R. R. Vivès, B. Priem, D. Bonnaffé, H. Lortat-Jacob, Y. Bourne, Proc Natl Acad Sci USA, 2019, 116, 6760-6765
A Versatile Electronic Tongue Based on Surface Plasmon Resonance Imaging and Cross-Reactive Sensor Arrays-A Mini-Review. L.-A. Garçon, M. Genua, Y.-J. Hou, R. Calemczuk, T. Livache, M. Billon, C. Le Narvor, D. Bonnaffé, H. Lortat-Jacob, Y. Hou, Sensors, 2017, 17, 1046
Repairing the Thiol-Ene Coupling Reaction. G. Povie, A.-T. Tran, D. Bonnaffe, J. Habegger, Z. Hu, C. Le Narvor, P. Renaud, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53, 3894-3898
Characterization of Glycosaminoglycan (GAG) Sulfatases from the Human Gut Symbiont Bacteroides thetaiotaomicron Reveals the First GAG-specific Bacterial Endosulfatase. J. E. Ulmer, E. M. Vilen, R. B. Namburi, A. Benjdia, J. Beneteau, A. Malleron, D. Bonnaffe, P.-A. Driguez, K. Descroix, G. Lassalle, C. Le Narvor, C. Sandstrom, D. Spillmann, O. Berteau, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289, 24289-24303