Chimie Bioorganique et Bioinorganique
1.1. Eco-design of drugs incorporating a self-immolable structure (ANR EDIFIS)
Problematic :
Emission of drugs and their metabolites without restriction in the environment: contamination of drinking water
Answer :
Development of a methodology based on programmed inactivation of eco-designed drugs:
- Predictably deactivatable drugs: a metabolically stable molecule in humans but unstable after excretion in the environment.
- Programmed inactivation of oxidized metabolites by inclusion of a self-immolating spacer
Participant :
Estelle Rascol, Postdoc ANR (01/04/2017-30/09/2018)
Collaboration :
Sylvie Nélieu, INRA/AgroParisTech