CP3A ORGANIC SYNTHESIS GROUP
Peptidomimetic Chemistry, Photochemistry, Alternative Processes
Flow chemistry
Soluble polymer-supported flow synthesis
We have shown that a PEG-supported multistep synthesis could be achieved in aqueous media under continuous flow conditions. PEG2000 offers a good compromise between charge capacity and recovery rate by ultrafiltration. The coupling of flow synthesis in water with ultrafiltration reduces the use of organic solvents in both the synthetic and purification steps, and allows safer working conditions.
See also “Chemistry in alternative solvents”
reference: Soluble polymer-supported flow synthesis: A green process for the preparation of heterocycles, Nicolò Prosa, Raphaël Turgis, Riccardo Piccardi, and Marie-Christine Scherrmann, Eur. J. Org. Chem. 2012, 2188–2200. DOI: 10.1002/ejoc.201101726