Institut de Chimie Moléculaire et des Matériaux d'Orsay

• Director of Equipe de Chimie Bioorganique et Bioinorganique (ECBB/ICMMO)
• Director of Master 2 Professionnel "Pollutions Chimiques et Gestion Environnementale" (PCGE)

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Research themes : Theme 1

• Aldonohydroxamic acids and other monosaccharidic analogues: synthesis, enzymatic evaluation and structural and physico-chemical studies. .
• Sugar metabolism enzymes (phosphoglucose isomerases and other aldose-ketose isomerases) : inhibition, structural and mechanistic studie .

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Teaching :

• Chemical modifications of proteins : L3 chimie-biologie
• Kinetic and mechanisms of enzymatic reactions : M1 chimie
• Biogeochemistry and chemistry of pollutants : M2 Pollutions Chimiques et Gestion Environnementale (PCGE)
• Kinetic, mechanisms and inhibition of enzymatic reactions : M2 Chimie Organique, M2 Ingeniérie et Chimie des Biomolécules (ICBM), et M2 Chimie Pharmaceutique

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Last publications :

Novel N-substituted 5-phosphate-D-arabinonamide derivatives as strong inhibitors of phosphoglucose isomerases: synthesis, structure-activity relationship and crystallographic studies. L. Ahmad, S. Plancqueel, N. Lazar, H. Korri-Youssoufi, I. Li de la Sierra-Gallay, H. van Tilbeurgh, L. Salmon, Bioorg. Chem. 2020, 102, 104048

Calibration of the dianionic phosphate group: Validation on the recognition site of the homodimeric enzyme phosphoglucose isomerase. M. Devillers, J.-P. Piquemal, L. Salmon, N. Gresh, J. Comput. Chem., 2020, 41, 839-854

Electrochemical detection of the human cancer biomarker ‘autocrine motility factor-phosphoglucose isomerase’ based on a biosensor formed with a monosaccharidic inhibitor. L. Ahmad, L. Salmon, H. Korri-Youssoufi, Sens. Actuators B Chem., 2019, 299, 126933

Bisphosphonate inhibitors of mammalian glycolytic aldolase. P. Heron, M. Abellán-Flos, L. Salmon, J. Sygusch, J. Med. Chem., 2018, 61, 10558-10572

Crystal Structure of Phosphomannose Isomerase from Candida albicans Complexed with 5‐Phospho‐D‐Arabinonhydrazide. L. Ahmad, S. Plancqueel, V. Dubosclard, N. Lazar, W. Ghattas, I. Li De La Sierra‐gallay, H. Van Tilbeurgh, L. Salmon, FEBS Lett., 2018, 592, 1667-1680

Carbohydrate-based electrochemical biosensor for detection of a cancer biomarker in human plasma. M. Devillers, L. Ahmad, H. Korri-Youssoufi, L. Salmon, Biosens. Bioelectron., 2017, 96, 178-185

Complexes of a Zn-metalloenzyme binding site with hydroxamate-containing ligands. A case for detailed benchmarkings of polarizable molecular mechanics/dynamics potentials when the experimental binding structure is unknown. N. Gresh, D. Perahia, B. De Courcy, J. Foret, C. Roux, L. El-Khoury, J.-P. Piquemal, L. Salmon, J. Comput. Chem., 2016, 37, 2770-2782

Structural Basis for Competitive Inhibition of 3,4-Dihydroxy-2-Butanone-4-Phosphate Synthase from Vibrio cholerae. Z. Islam, A. Kumar, S. Singh, L. Salmon, S. Karthikeyan, J. Biol. Chem., 2015, 290, 11293-11308