Laurent Salmon
Build. 420, office 117 – LCBB – ICMMO
Université Paris-Saclay
Rue du doyen Georges Poitou
91405 Orsay Cedex
FRANCE
+33 1 69 15 63 11
laurent.salmon@u-psud.fr
https://orcid.org/0000-0003-1946-8458
- Director of Equipe de Chimie Bioorganique et Bioinorganique (ECBB/ICMMO)
- Director of Master 2 Professionnel "Pollutions Chimiques et Gestion Environnementale" (PCGE)
Research themes : Theme 1
- Aldonohydroxamic acids and other monosaccharidic analogues: synthesis, enzymatic evaluation and structural and physico-chemical studies. .
- Sugar metabolism enzymes (phosphoglucose isomerases and other aldose-ketose isomerases) : inhibition, structural and mechanistic studie .
Teaching :
- Chemical modifications of proteins : L3 chimie-biologie
- Kinetic and mechanisms of enzymatic reactions : M1 chimie
- Biogeochemistry and chemistry of pollutants : M2 Pollutions Chimiques et Gestion Environnementale (PCGE)
- Kinetic, mechanisms and inhibition of enzymatic reactions : M2 Chimie Organique, M2 Ingeniérie et Chimie des Biomolécules (ICBM), et M2 Chimie Pharmaceutique
Last publications :
Novel N-substituted 5-phosphate-D-arabinonamide derivatives as strong inhibitors of phosphoglucose isomerases: synthesis, structure-activity relationship and crystallographic studies. L. Ahmad, S. Plancqueel, N. Lazar, H. Korri-Youssoufi, I. Li de la Sierra-Gallay, H. van Tilbeurgh, L. Salmon, Bioorg. Chem. 2020, 102, 104048
Calibration of the dianionic phosphate group: Validation on the recognition site of the homodimeric enzyme phosphoglucose isomerase. M. Devillers, J.-P. Piquemal, L. Salmon, N. Gresh, J. Comput. Chem., 2020, 41, 839-854
Electrochemical detection of the human cancer biomarker ‘autocrine motility factor-phosphoglucose isomerase’ based on a biosensor formed with a monosaccharidic inhibitor. L. Ahmad, L. Salmon, H. Korri-Youssoufi, Sens. Actuators B Chem., 2019, 299, 126933
Bisphosphonate inhibitors of mammalian glycolytic aldolase. P. Heron, M. Abellán-Flos, L. Salmon, J. Sygusch, J. Med. Chem., 2018, 61, 10558-10572
Crystal Structure of Phosphomannose Isomerase from Candida albicans Complexed with 5‐Phospho‐D‐Arabinonhydrazide. L. Ahmad, S. Plancqueel, V. Dubosclard, N. Lazar, W. Ghattas, I. Li De La Sierra‐gallay, H. Van Tilbeurgh, L. Salmon, FEBS Lett., 2018, 592, 1667-1680
Carbohydrate-based electrochemical biosensor for detection of a cancer biomarker in human plasma. M. Devillers, L. Ahmad, H. Korri-Youssoufi, L. Salmon, Biosens. Bioelectron., 2017, 96, 178-185