Wadih Ghattas

Journal articles

2026

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Rabiaa Helim, Ali Zazoua, Wadih Ghattas, Hafsa Korri-Youssoufi. Polypyrrole-Hemicellulose Composite Based Electrochemical Sensor for Pb(II) Detection and Quantification in Water. Journal of The Electrochemical Society, 2026, 173 (1), pp.017501. ⟨10.1149/1945-7111/ae320e⟩. ⟨hal-05457895⟩

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2025

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Morane Beaumet, Sarah Wiorek, Jean-Pierre Mahy, Wadih Ghattas. Metal‐Complexes Biomimetic of Metallo‐β‐Lactamases. European Journal of Inorganic Chemistry, 2025, 28 (29), ⟨10.1002/ejic.202500194⟩. ⟨hal-05397390⟩

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2024

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Rémy Gay, Yannick Masson, Wadih Ghattas, Guillermo a Oliveira Udry, Christian Herrero, et al.. Binding and stabilization of a semiquinone radical by an artificial metalloenzyme containing a binuclear copper (II) cofactor. ChemBioChem, 2024, ⟨10.1002/cbic.202400139⟩. ⟨hal-04782247⟩

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2022

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Morane Beaumet, Anica Dose, Alois Bräuer, Jean-Pierre Mahy, Wadih Ghattas, et al.. An artificial metalloprotein with metal-adaptive coordination sites and Ni-dependent quercetinase activity. Journal of Inorganic Biochemistry, 2022, 235, pp.111914. ⟨10.1016/j.jinorgbio.2022.111914⟩. ⟨hal-03738425⟩

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Morane Beaumet, Anica Dose, Alois Bräuer, Jean-Pierre Mahy, Wadih Ghattas, et al.. An artificial metalloprotein with metal-adaptive coordination sites and Ni-dependent quercetinase activity. Journal of Inorganic Biochemistry, 2022, 235, ⟨10.1016/j.jinorgbio.2022.111914⟩. ⟨hal-03876408⟩

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Wadih Ghattas, Morane Beaumet, Jean-Pierre Mahy. Les Métalloenzymes Artificielles, des perspectives de la biocatalyse à la médecine. L’Actualité Chimique, 2022, 479, pp.61-65. ⟨hal-04310237⟩

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2021

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Nada Elgiddawy, Shiwei Ren, Wadih Ghattas, Waleed M a El Rouby, Ahmed O El-Gendy, et al.. Bio-Based Materials for Electrochemical Detection of Bisphenol A. Sensors, 2021, 21, pp.1715. ⟨10.3390/s21051715⟩. ⟨hal-04937986⟩

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Nada Elgiddawy, Shiwei Ren, Wadih Ghattas, Waleed M a El Rouby, Ahmed O El-Gendy, et al.. Antimicrobial Activity of Cationic Poly(3-hexylthiophene) Nanoparticles Coupled with Dual Fluorescent and Electrochemical Sensing: Theragnostic Prospect. Sensors, 2021, 21 (5), pp.1715. ⟨10.3390/s21051715⟩. ⟨hal-03421241⟩

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Wadih Ghattas, Jean-Pierre Mahy, Rémy Ricoux, A. Jalila Simaan, Marius Réglier. Diels-alderases artificielles au service de la chimie verte. Techniques de l’Ingénieur, 2021, ⟨10.51257/a-v1-in404⟩. ⟨hal-03457927⟩

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Wadih Ghattas, Jean-Pierre Mahy, Marius Réglier, A. Jalila Simaan. Artificial enzymes for Diels‐Alder reactions. ChemBioChem, 2021, 22 (3), pp.443-459. ⟨10.1002/cbic.202000316⟩. ⟨hal-02984513⟩

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2020

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Fréderic Avenier, Wadih Ghattas, Rémy Ricoux, Jean-Pierre Mahy. Recent progress in the development of new artificial metalloenzymes as biocatalysts for selective oxidations and Diels‐Alder reaction ‐ Mini‐Review. Vietnam Journal of Chemistry, 2020, 58 (4), pp.423-433. ⟨10.1002/vjch.202000033⟩. ⟨hal-05549679⟩

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Fréderic Avenier, Wadih Ghattas, Rémy Ricoux, Jean-Pierre Mahy. Recent progress in the development of new artificial metalloenzymes as biocatalysts for selective oxidations and Diels-Alder reaction -Mini-Review. Vietnam Journal of Chemistry, 2020, 58 (4), pp.423-433. ⟨10.1002/vjch.202000033⟩. ⟨hal-03099261⟩

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Wadih Ghattas, Jean-Pierre Mahy, Marius Réglier, A. Jalila Simaan. Artificial enzymes for Diels‐Alder reactions. ChemBioChem, In press, ⟨10.1002/cbic.202000316⟩. ⟨hal-03098285⟩

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Kalani Kariyawasam, Wadih Ghattas, Yossef López de Los Santos, Nicolas Doucet, Sylvain Gaillard, et al.. Artificial iron hydrogenase made by covalent grafting of Knölker’s complex into xylanase: Application in asymmetric hydrogenation of an aryl ketone in water. Biotechnology and Applied Biochemistry, 2020, Synthetic and Engineered Enzymes for Biocatalysis and Biotransformation, 67, pp.563-573. ⟨10.1002/bab.1906⟩. ⟨hal-03098292⟩

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Kalani Kariyawasam, Wadih Ghattas, Yossef López de los Santos, Nicolas Doucet, Sylvain Gaillard, et al.. Artificial iron hydrogenase made by covalent grafting of Knölker’s complex into xylanase: Application in asymmetric hydrogenation of an aryl ketone in water. Biotechnology and Applied Biochemistry, 2020, 67 (4), pp.563-573. ⟨10.1002/bab.1906⟩. ⟨hal-05523324⟩

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2019

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Thibault Di Meo, Kalani Kariyawasam, Wadih Ghattas, Marie Valerio-Lepiniec, Giuseppe Sciortino, et al.. Functionalized Artificial Bidomain Proteins Based on an alpha-Solenoid Protein Repeat Scaffold: A New Class of Artificial Diels-Alderases. ACS Omega, 2019, 4 (2), pp.4437–4447. ⟨10.1021/acsomega.8b03448⟩. ⟨hal-02170233⟩

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Wadih Ghattas, Virginie Dubosclard, Sybille Tachon, Morane Beaumet, Régis Guillot, et al.. CuII ‐Containing 1‐Aminocyclopropane Carboxylic Acid Oxidase Is an Efficient Stereospecific Diels–Alderase. Angewandte Chemie, 2019, 131 (41), pp.14747-14751. ⟨10.1002/ange.201909407⟩. ⟨hal-02299031⟩

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2018

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Lama Ahmad, Stéphane Plancqueel, Virginie Dubosclard, Noureddine Lazar, Wadih Ghattas, et al.. Crystal structure of phosphomannose isomerase from Candida albicans complexed with 5-phospho-d-arabinonhydrazide. FEBS Letters, 2018, 592 (10), pp.1667–1680. ⟨10.1002/1873-3468.13059⟩. ⟨hal-02175121⟩

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2017

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Thibault Di Meo, Wadih Ghattas, Christian Herrero, Christophe Velours, Philippe Minard, et al.. αRep A3: A versatile artificial scaffold for metalloenzyme design. Chemistry – A European Journal, 2017, ⟨10.1002/chem.201701518⟩. ⟨hal-02191704⟩

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2016

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Wadih Ghattas, Lur Cotchico-Alonso, Jean-Didier Maréchal, Agathe Urvoas, Maëva Rousseau, et al.. Artificial Metalloenzymes with the Neocarzinostatin Scaffold: Toward a Biocatalyst for the Diels-Alder Reaction. ChemBioChem, 2016, 17 (5), pp.433–440. ⟨10.1002/cbic.201500445⟩. ⟨hal-02393787⟩

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2015

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Y Roux, Wadih Ghattas, Frédéric Avenier, Regis Guillot, Ariane Jalila Simaan, et al.. Synthesis and characterization of [Fe(BPMEN)-ACC]SbF 6 : a structural and functional mimic of ACC-oxidase †. Dalton Transactions, 2015, 44 (13), pp.5966-5968. ⟨10.1039/c5dt00347d⟩. ⟨hal-01258299⟩

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Y. Roux, Wadih Ghattas, F. Avenier, R. Guillot, A. Simaan, et al.. Synthesis and characterization of [Fe(BPMEN)ACC]SbF 6 : a structural and functional mimic of ACC-oxidase. Dalton Transactions, 2015, 44 (13), pp.5966-5968. ⟨10.1039/c5dt00347d⟩. ⟨hal-05549722⟩

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2014

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Agathe Urvoas, Wadih Ghattas, Jean-Didier Maréchal, Frédéric Avenier, Felix Bellande, et al.. Neocarzinostatin-based hybrid biocatalysts with a RNase like activity. Bioorganic and Medicinal Chemistry, 2014, 22 (20), pp.5678-5686. ⟨10.1016/j.bmc.2014.05.063⟩. ⟨hal-05549728⟩

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2010

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Emma Langella, Sébastien Pierre, Wadih Ghattas, Michel Giorgi, M. Réglier, et al.. Probing the Peptidylglycine α-Hydroxylating Monooxygenase Active Site with Novel 4-Phenyl-3-butenoic Acid Based Inhibitors. ChemMedChem, 2010, 5 (9), pp.1568-1576. ⟨hal-01948940⟩

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2009

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Eugénie Peyroux, Wadih Ghattas, Renaud Hardré, Michel Giorgi, Bruno Faure, et al.. Binding of 2-Hydroxypyridine- N -oxide on Dicopper(II) Centers: Insights into Tyrosinase Inhibition Mechanism by Transition-State Analogs. Inorganic Chemistry, 2009, 48 (23), pp.10874 – 10876. ⟨10.1021/ic901593x⟩. ⟨hal-01658950⟩

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2008

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Wadih Ghattas, Michel Giorgi, Yasmina Mekmouche, Tsunehiro Tanaka, Antal Rockenbauer, et al.. Identification of a Copper(I) Intermediate in the Conversion of 1-Aminocyclopropane Carboxylic Acid (ACC) into Ethylene by Cu(II)−ACC Complexes and Hydrogen Peroxide. Inorganic Chemistry, 2008, 47 (11), pp.4627-4638. ⟨hal-01948939⟩

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2007

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Wadih Ghattas, Michel Giorgi, Christian Gaudin, Antal Rockenbauer, Marius Réglier, et al.. Characterization of Cu(II)-ACC Complexes and Conversion of the Bound ACC into Ethylene in the Presence of Hydrogen Peroxide. Detection of a Brown Intermediate at Low Temperature. Bioinorganic Chemistry and Applications, 2007, 2007, pp.43424. ⟨10.1155/2007/43424⟩. ⟨hal-02299044⟩

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2006

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Wadih Ghattas, Christian Gaudin, Michel Giorgi, Antal Rockenbauer, A. Jalila Simaan, et al.. ACC-Oxidase like activity of a copper (ii)–ACC complex in the presence of hydrogen peroxide. Detection of a reaction intermediate at low temperature. Chemical Communications, 2006, 9, pp.1027. ⟨10.1039/b515374c⟩. ⟨hal-02096709⟩

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Wadih Ghattas, Corinna Hess, Gilles Iacazio, Renaud M Hardré, Judith Klinman, et al.. Pathway for the Stereocontrolled Z and E Production of α,α-Difluorine-Substituted Phenyl Butenoates. Journal of Organic Chemistry, 2006, 71 (22), pp.8618-8621. ⟨hal-01948927⟩

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Conference papers

2018

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Cyrille Sabot, Laura Nogueira de Faria Cardoso, Pierre-Yves Renard, Wadih Ghattas, Jean-Pierre Mahy. Méthode de criblage : identification de catalyseurs de la réaction de Diels-Alder. Journée scientifique du LabEx Chimie des Architectures Moléculaires Multifonctionnelles et des Matériaux (CHARMMMAT, 6, 2018)), Jun 2018, Cachan, France. ⟨hal-03098307⟩

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Cyrille Sabot, Laura Nogueira de Faria Cardoso, Pierre-Yves Renard, Wadih Ghattas, Jean-Pierre Mahy. Méthode de criblage : identification de catalyseurs de la réaction de Diels-Alder. Journée scientifique du LabEx Chimie des Architectures Moléculaires Multifonctionnelles et des Matériaux (CHARMMMAT, 6, 2018)), Jun 2018, Cachan, France. ⟨hal-02372510⟩

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Book sections

2023

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Frédéric Avenier, Wadih Ghattas, Rémy Ricoux, Jean-Pierre Mahy. Chemistry for a Better Life: Elaborating Artificial Metalloenzymes for Eco-compatible Chemical Synthesis Procedures and Therapeutic Applications. Peptide and Protein Engineering for Biotechnological and Therapeutic Applications, WORLD SCIENTIFIC, pp.469-504, 2023, ⟨10.1142/9789811261664_0012⟩. ⟨hal-04782310⟩

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2020

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Jean-Pierre Mahy, Frédéric Avenier, Wadih Ghattas, Rémy Ricoux, Michele Salmain. Current Applications of Artificial Metalloenzymes and Future Developments. Enzymes for Solving Humankind’s Problems, pp.363 – 411, 2020, ⟨10.1007/978-3-030-58315-6_12⟩. ⟨hal-03100142⟩

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