Journal articles

2026

Stefano Barranco, Dianya Fu, Angelo Frongia, Sandrine Deloisy, David J Aitken. Synthesis of C1-quaternary 1-(α-methylbenzylamino)cyclobutane derivatives. Tetrahedron Letters, 2026, 185, pp.156271. ⟨10.1016/j.tetlet.2026.156271⟩. ⟨hal-05840527⟩

Assia Keniche, Soltani Yassemine Ikram, Zoheir Arrar, Mohammed El Amine Dib, El Ouar Ibtissem, et al.. Chemical Profiling, Antimicrobial and Anti-Neurodegenerative Activities of Ethanol Extracts of Propolis and their β-Cyclodextrin Complexes from Northwestern Algeria. Chemistry Africa, 2026, 9 (7), pp.323. ⟨10.1007/s42250-026-01821-7⟩. ⟨hal-05840532⟩

M. Chiara Cabua, Davide Moi, Emanuele Cocco, Valentina Onnis, Enrico Podda, et al.. Catalytic Enantioselective Synthesis of Conformationally Stable C(sp 2 )−C(sp 3 ) Naphthocoumarin Atropisomers. Advanced Synthesis and Catalysis, 2026, 368 (9), ⟨10.1002/adsc.70425⟩. ⟨hal-05840538⟩

Mauro Uras, Michela Vargiu, Adèle Gegout, Abdikafi Hassan Mohamed, Régis Guillot, et al.. Skeletal reorganization of cyclobutane-fused bicyclic γ-lactams: synthesis of spirocyclopropyl α,β-unsaturated γ-lactams. Organic Chemistry Frontiers, 2026, 13 (19), pp.6758-6764. ⟨10.1039/D6QO00822D⟩. ⟨hal-05771698⟩

2025

Zeynab Imani, Viola D’mello, Venkateswara Mundlapati, Catherine Gourson, Régis Guillot, et al.. A Theoretical and Spectroscopic Conformational Study of 3-Aminothiolane-3-Carboxylic Acid Dipeptide Derivatives. Molecules, 2025, 30 (23), pp.4547. ⟨10.3390/molecules30234547⟩. ⟨hal-05771663⟩

Stefano Barranco, Mauro Uras, Veronica Frau, Pierluigi Caboni, Régis Guillot, et al.. Synthesis of β‐N‐Heterocyclic‐Cyclobutane‐Fused Bicyclic γ‐Lactones from 2‐Hydroxycyclobutanone and Carboxamide‐Bearing Wittig Reagents. European Journal of Organic Chemistry, 2025, 28 (26), ⟨10.1002/ejoc.202500332⟩. ⟨hal-05771652⟩

Maria Chiara Cabua, Xuefeng He, Francesco Secci, Sandrine Deloisy, David Aitken. Rapid Synthesis of anti ‐1,3‐Diamino‐4‐phenylbutan‐2‐ol Building Blocks via a Three‐Component Oxyhomologation and a Two‐Component Reducing System. ChemistryOpen, 2025, 14 (2), ⟨10.1002/open.202400279⟩. ⟨hal-05849039⟩

Dayi Liu, Ali T Mansour, Ogaritte Yazbeck, Daoud Naoufal, Sylvie Robin, et al.. Stereochemical matching determines both helix type and handedness in α/γ-peptides with a cyclic-constrained γ-amino acid. Chemical Communications, 2025, 61 (38), pp.6925-6928. ⟨10.1039/d5cc00746a⟩. ⟨hal-05374537⟩

2024

Xiaodan Yu, Arthur Desvals, Zong Chang, Vincent Orève, David Aitken, et al.. Light-Initiated Four-Step Domino-Multicomponent Synthesis of Functionalized Alkylidenecyclobutanes. Organic Letters, 2024, 26 (46), pp.9915-9919. ⟨10.1021/acs.orglett.4c03741⟩. ⟨hal-04816309⟩

Stefano Barranco, Federico Cuccu, Federico Devoto, Régis Guillot, Pierluigi Caboni, et al.. Synthesis of cyclobutane-fused oxazolidine-2-thione derivatives. Tetrahedron Letters, 2024, 139, pp.155009. ⟨10.1016/J.TETLET.2024.155009⟩. ⟨hal-05771634⟩

Xuefeng He, Régis Guillot, Sandrine Deloisy, David Aitken. High anti Diastereoselectivity in a Tandem Oxyhomologation–Coupling Protocol for the Preparation of Amides and Peptides Incorporating α-Hydroxy β-Amino Acids. Organic Letters, 2024, 26 (11), pp.2207-2211. ⟨10.1021/ACS.ORGLETT.4C00370⟩. ⟨hal-05771643⟩

Stefano Barranco, Alessio Pagnanini, Federico Cuccu, Pierluigi Caboni, Régis Guillot, et al.. Substrate-dependent regiodivergence in [3 + 2] annulation reactions of 2-(phenacylethylidene)cyclobutanones with thioureas. Organic & Biomolecular Chemistry, 2024, 22 (39), pp.8048-8053. ⟨10.1039/D4OB01103A⟩. ⟨hal-05771637⟩

Dayi Liu, Sylvie Robin, Eric Gloaguen, Valérie Brenner, Michel Mons, et al.. Effects of sulfoxide and sulfone sidechain–backbone hydrogen bonding on local conformations in peptide models. Chemical Communications, 2024, 60 (15), pp.2074-2077. ⟨10.1039/d3cc05933b⟩. ⟨hal-04729580⟩

2023

Xiaodan Yu, Thomas Boddaert, David Aitken. Functionalized Alkylidenecyclobutanes from a Cyclopent‐2‐enone Substrate via a Tandem Photochemical Transformation and an Allylic Substitution Protocol. Advanced Synthesis and Catalysis, 2023, 365 (22), pp.4002-4007. ⟨10.1002/adsc.202300798⟩. ⟨hal-04750914⟩

Dayi Liu, Régis Guillot, Sylvie Robin, David Aitken. trans-3-Benzyloxycarbonylamino-1-methyl-3-(methylcarbamoyl)azetidine-1-oxide. Molbank, 2023, 2023 (3), pp.M1726. ⟨10.3390/M1726⟩. ⟨hal-05771626⟩

Dayi Liu, Jean-Xavier Bardaud, Zeynab Imani, Sylvie Robin, Eric Gloaguen, et al.. Length-Dependent Transition from Extended to Folded Shapes in Short Oligomers of an Azetidine-Based α-Amino Acid: The Critical Role of NH···N H-Bonds. Molecules, 2023, 28 (13), pp.5048. ⟨10.3390/molecules28135048⟩. ⟨hal-04234958⟩

Dayi Liu, Zeynab Imani, Catherine Gourson, Régis Guillot, Sylvie Robin, et al.. A Post-Synthetic Modification Strategy for the Preparation of Homooligomers of 3-Amino-1-methylazetidine-3-carboxylic Acid. SYNLETT, 2023, 34 (15), pp.1787-1790. ⟨10.1055/A-2071-4122⟩. ⟨hal-05771624⟩

Stefano Barranco, Federico Cuccu, Dayi Liu, Sylvie Robin, Régis Guillot, et al.. β‐ N ‐heterocyclic cyclobutane carboximides: synthesis through a tandem base‐catalyzed amidation/aza‐Michael addition protocol and facile transformations. European Journal of Organic Chemistry, 2023, 26 (16), pp.e202300183. ⟨10.1002/ejoc.202300183⟩. ⟨cea-04453341⟩

Zeynab Imani, V. Rao Mundlapati, Valérie Brenner, Eric Gloaguen, Katia Le Barbu-Debus, et al.. Non-covalent interactions reveal the protein chain δ conformation in a flexible single-residue model. Chemical Communications, 2023, ⟨10.1039/D2CC06658K⟩. ⟨hal-03923111⟩

2022

Maria Lapuh, Gabriel Cormier, Slimane Chergui, David Aitken, Thomas Boddaert. Preparation of Thietane Derivatives through Domino Photochemical Norrish Type II/Thia-Paternò–Büchi Reactions. Organic Letters, 2022, 24 (45), pp.8375-8380. ⟨10.1021/acs.orglett.2c03428⟩. ⟨hal-04750905⟩

Viola d’Mello, Gildas Goldsztejn, Venkateswara Rao Mundlapati, Valérie Brenner, Eric Gloaguen, et al.. Front Cover: Characterization of Asx Turn Types and Their Connate Relationship with β‐Turns (Chem. Eur. J. 25/2022). Chemistry – A European Journal, 2022, 28 (25), ⟨10.1002/chem.202200968⟩. ⟨hal-03917656⟩

Viola d’Mello, Gildas Goldsztejn, Venkateswara Rao Mundlapati, Valérie Brenner, Eric Gloaguen, et al.. Characterization of Asx-turn types and their connate relationship with β-turns. Chemistry – A European Journal, 2022, 28 (25), pp.e202104328. ⟨10.1002/chem.202104328⟩. ⟨hal-03808270⟩

Xuefeng He, Marie Buchotte, Régis Guillot, Sandrine Deloisy, David Aitken. A case study of the MAC (masked acyl cyanide) oxyhomologation of N , N -dibenzyl- l -phenylalaninal with anti diastereoselectivity: preparation of (2 S ,3 S )-allophenylnorstatin esters. Organic & Biomolecular Chemistry, 2022, 20 (8), pp.1769-1781. ⟨10.1039/D1OB02411F⟩. ⟨hal-05771350⟩

2021

Venkateswara Rao Mundlapati, Zeynab Imani, Viola d’Mello, Valérie Brenner, Eric Gloaguen, et al.. N–H⋯X interactions stabilize intra-residue C5 hydrogen bonded conformations in heterocyclic $\alpha$-amino acid derivatives. Chemical Science, 2021, 12 (44), pp.14826-14832. ⟨10.1039/D1SC05014A⟩. ⟨cea-03543435⟩

Florence Charnay-Pouget, Matthieu Le Liepvre, Hendrik Eijsberg, Régis Guillot, Jean Ollivier, et al.. A short synthesis of both enantiomers of 2-aminobicyclo[3.2.0]heptane-2,7-dicarboxylic acid. Tetrahedron Letters, 2021, 68, pp.152912. ⟨10.1016/j.tetlet.2021.152912⟩. ⟨hal-03917652⟩

Jeremy Donon, Sana Habka, Thibaut Very, Florence D J Charnay-Pouget, Michel Mons, et al.. Ion pair supramolecular structure identified by ATR-FTIR spectroscopy and simulations in explicit solvent. ChemPhysChem, 2021, 22 (23), pp.2442-2455. ⟨10.1002/cphc.202100565⟩. ⟨hal-03783652⟩

Venkateswara Rao Mundlapati, Zeynab Imani, Gildas Goldsztejn, Eric Gloaguen, Valérie Brenner, et al.. A theoretical and experimental case study of the hydrogen bonding predilection of S-methylcysteine. Amino Acids, 2021, 53 (4), pp.621-633. ⟨10.1007/s00726-021-02967-z⟩. ⟨hal-03186714⟩

Valentina Marras, Pierluigi Caboni, Francesco Secci, Régis Guillot, David Aitken, et al.. A Brønsted acid catalyzed tandem reaction for the diastereoselective synthesis of cyclobuta-fused tetrahydroquinoline carboxylic esters. Organic & Biomolecular Chemistry, 2021, 19 (41), pp.8912-8916. ⟨10.1039/D1OB01518D⟩. ⟨hal-05771314⟩

2020

Ahmad Kassir, Régis Guillot, Marie-Christine Scherrmann, Thomas Boddaert, David Aitken. Formation of Tetrahydrothiophenes via a Thia-Paternò–Büchi-Initiated Domino Photochemical Reaction. Organic Letters, 2020, 22 (21), pp.8522-8527. ⟨10.1021/acs.orglett.0c03128⟩. ⟨hal-04750910⟩

Zeynab Imani, Régis Guillot, Valérie Declerck, David Aitken. Local versus Global Control of Helical Folding in β-Peptide Segments Using Hydrazino Turns. Journal of Organic Chemistry, 2020, 85 (9), pp.6165-6171. ⟨10.1021/acs.joc.0c00305⟩. ⟨hal-05771273⟩

Zeynab Imani, Venkateswara Rao Mundlapati, Gildas Goldsztejn, Valerie Brenner, Eric Gloaguen, et al.. Conformation control through concurrent N–H⋯S and N–H⋯O=C hydrogen bonding and hyperconjugation effects. Chemical Science, 2020, 11, pp.9191-9197. ⟨10.1039/D0SC03339A⟩. ⟨hal-02917912⟩

2019

Zong Chang, Régis Guillot, Thomas Boddaert, David Aitken. Stereocontrolled Preparation of Diversely Trifunctionalized Cyclobutanes. Journal of Organic Chemistry, 2019, 84 (16), pp.10518-10525. ⟨10.1021/ACS.JOC.9B01463⟩. ⟨hal-05771185⟩

Sana Habka, Thibaut Véry, Jeremy Donon, Vanesa Vaquero-Vara, Benjamin Tardivel, et al.. Identification of ion pairs in solution by IR spectroscopy: crucial contributions of gas phase data and simulations. Physical Chemistry Chemical Physics, 2019, 21 (24), pp.12798-12805. ⟨10.1039/c9cp00700h⟩. ⟨cea-02160902⟩

Sana Habka, Thibaut Very, Jeremy Donon, Vanesa Vaquero-Vara, Benjamin Tardivel, et al.. Identification of ion pairs in solution by IR spectroscopy: crucial contributions of gas phase data and simulations. Physical Chemistry Chemical Physics, 2019, 21 (24), pp.12798-12805. ⟨10.1039/c9cp00700h⟩. ⟨hal-03917603⟩

Valérie Declerck, Ariel Pérez-Mellor, Régis Guillot, David Aitken, Michel Mons, et al.. Vibrational circular dichroism as a probe of solid‐state organisation of derivatives of cyclic β‐amino acids: Cis ‐ and trans ‐2‐aminocyclobutane‐1‐carboxylic acid. Chirality, 2019, 31 (8), pp.547-560. ⟨10.1002/chir.23083⟩. ⟨hal-02347980⟩

Mathieu Esgulian, Marie Buchotte, Régis Guillot, Sandrine Deloisy, David Aitken. Reversal of Diastereoselectivity in a Masked Acyl Cyanide (MAC) Reaction: Synthesis of Protected erythro -β-Hydroxyaspartate Derivatives. Organic Letters, 2019, 21 (7), pp.2378-2382. ⟨10.1021/ACS.ORGLETT.9B00664⟩. ⟨hal-05771192⟩

Lorenza Ghisu, Nicola Melis, Lorenzo Serusi, Alberto Luridiana, Francesco Soddu, et al.. Synthesis of β-sulfinyl cyclobutane carboxylic amides via a formal α to β sulphoxide migration process. Organic & Biomolecular Chemistry, 2019, 17 (25), pp.6143-6147. ⟨10.1039/C9OB00758J⟩. ⟨hal-05771173⟩

2018

Stefania Porcu, Stefania Demuro, Alberto Luridiana, Andrea Cocco, Angelo Frongia, et al.. Brønsted Acid Mediated Cascade Reaction To Access 3-(2-Bromoethyl)benzofurans. Organic Letters, 2018, 20 (23), pp.7699-7702. ⟨10.1021/acs.orglett.8b03429⟩. ⟨hal-03917605⟩

Julien Buendia, Zong Chang, Hendrik Eijsberg, Régis Guillot, Angelo Frongia, et al.. Preparation of Cyclobutene Acetals and Tricyclic Oxetanes through Photochemical Tandem and Cascade Reactions. Angewandte Chemie, 2018, 130 (22), pp.6702-6706. ⟨10.1002/ange.201803571⟩. ⟨hal-04336159⟩

Stefania Porcu, Alberto Luridiana, Alberto Martis, Angelo Frongia, Giorgia Sarais, et al.. Acid-catalyzed synthesis of functionalized arylthio cyclopropane carbaldehydes and ketones. Chemical Communications, 2018, 54 (96), pp.13547-13550. ⟨10.1039/C8CC07571A⟩. ⟨hal-05771084⟩

Sherif Ragab, Ahmad Kassir, Régis Guillot, Marie-Christine Scherrmann, Thomas Boddaert, et al.. Cooperative 5- and 10-membered ring interactions in the 10-helix folding of oxetin homo-oligomers. Chemical Communications, 2018, 54 (16), pp.1968-1971. ⟨10.1039/C7CC09964A⟩. ⟨hal-05771070⟩

2017

Zong Chang, France Boyaud, Régis Guillot, Thomas Boddaert, David Aitken. A Photochemical Route to 3- and 4-Hydroxy Derivatives of 2-Aminocyclobutane-1-carboxylic Acid with an all-cis Geometry. Journal of Organic Chemistry, 2017, 83 (1), pp.527-534. ⟨10.1021/ACS.JOC.7B02559⟩. ⟨hal-05771091⟩

Anaïs Gondoin, Cornelia Hampe, Richard Eudes, Cyril Fayolle, Cécile Pierre-Eugène, et al.. Identification of insulin-sensitizing molecules acting by disrupting the interaction between the Insulin Receptor and Grb14. Scientific Reports, 2017, 7 (1), pp.16901. ⟨10.1038/s41598-017-17122-6⟩. ⟨hal-03917614⟩

Nicola Melis, Alberto Luridiana, Régis Guillot, Francesco Secci, Angelo Frongia, et al.. Stereoselective and Regioselective Pinacol‐Type Rearrangement of a Fused Bicyclic Oxetanol Scaffold. European Journal of Organic Chemistry, 2017, 2017 (39), pp.5896-5902. ⟨10.1002/EJOC.201701214⟩. ⟨hal-05770997⟩

Ali Mansour, Julien Buendia, Juan Xie, François Brisset, Sylvie Robin, et al.. β-Cyclodextrin-Mediated Enantioselective Photochemical Electrocyclization of 1,3-Dihydro-2H-azepin-2-one. Journal of Organic Chemistry, 2017, 82 (18), pp.9832-9836. ⟨10.1021/acs.joc.7b01300⟩. ⟨hal-04346896⟩

Hawraà Awada, Claire Grison, Florence Charnay-Pouget, Jean-Pierre Baltaze, François Brisset, et al.. Conformational Effects through Hydrogen Bonding in a Constrained γ-Peptide Template: From Intraresidue Seven-Membered Rings to a Gel-Forming Sheet Structure. Journal of Organic Chemistry, 2017, 82 (9), pp.4819-4828. ⟨10.1021/acs.joc.7b00494⟩. ⟨hal-03917615⟩

Mathieu Esgulian, Vincent Belot, Régis Guillot, Sandrine Deloisy, David Aitken. Studies on cyclization reactions of 3-amino-2,4-dihydroxybutanoic acid derivatives. Organic & Biomolecular Chemistry, 2017, 15 (6), pp.1453-1462. ⟨10.1039/C6OB02759H⟩. ⟨hal-05770991⟩

Alberto Martis, Alberto Luridiana, Angelo Frongia, Massimiliano Arca, Giorgia Sarais, et al.. Acid-catalyzed reaction of 2-hydroxycyclobutanone with benzylic alcohols. Organic & Biomolecular Chemistry, 2017, 15 (47), pp.10053-10063. ⟨10.1039/C7OB02545A⟩. ⟨hal-05771027⟩

Lorenza Ghisu, Nicola Melis, Francesco Secci, Pierluigi Caboni, Massimiliano Arca, et al.. Synthesis of 2,2-bis(pyridin-2-yl amino)cyclobutanols and their conversion into 5-(pyridin-2-ylamino)dihydrofuran-2(3 H )-ones. Organic & Biomolecular Chemistry, 2017, 15 (46), pp.9779-9784. ⟨10.1039/C7OB02567J⟩. ⟨hal-05770980⟩

2016

Ahmad Kassir, Sherif Ragab, Thao Nguyen, Florence Charnay-Pouget, Régis Guillot, et al.. Synthetic Access to All Four Stereoisomers of Oxetin. Journal of Organic Chemistry, 2016, 81 (20), pp.9983-9991. ⟨10.1021/acs.joc.6b01795⟩. ⟨hal-03917617⟩

Claire M. Grison, Jennifer A Miles, Sylvie Robin, Andrew J Wilson, David J Aitken. An α-Helix-Mimicking 12,13-Helix: Designed α/β/γ-Foldamers as Selective Inhibitors of Protein-Protein Interactions. Angewandte Chemie International Edition, 2016, 55 (37), pp.11096-11100. ⟨10.1002/anie.201604517⟩. ⟨hal-05381729⟩

S. Safi, A. Jeanson, J. Roques, P. L. Solari, F. Charnay-Pouget, et al.. Thermodynamic and Structural Investigation of Synthetic Actinide–Peptide Scaffolds. Inorganic Chemistry, 2016, 55 (2), pp.877-886. ⟨10.1021/acs.inorgchem.5b02379⟩. ⟨in2p3-01298558⟩

Alberto Luridiana, Angelo Frongia, David Aitken, Régis Guillot, Giorgia Sarais, et al.. Deracemizing organocatalyzed Michael addition reactions of 2-(arylthio)cyclobutanones with β-nitrostyrenes. Organic & Biomolecular Chemistry, 2016, 14 (13), pp.3394-3403. ⟨10.1039/C6OB00160B⟩. ⟨hal-05770964⟩

2015

Mohammad Alauddin, Eric Gloaguen, Valérie Brenner, Benjamin Tardivel, Michel Mons, et al.. Local folding proclivities in cyclic b -peptide building blocks: assessment of configuration and heteroatom substitution effects by gas phase conformer-selective laser spectroscopy and quantum chemistry . Chemistry – A European Journal, 2015, 21 (46), pp.16479-16493 ⟨10.1002/chem.201501794⟩. ⟨cea-01273006⟩

Amandine Altmayer-Henzien, Valérie Declerck, Jonathan Farjon, Denis Merlet, Régis Guillot, et al.. Fine Tuning of β‐Peptide Foldamers: a Single Atom Replacement Holds Back the Switch from an 8‐Helix to a 12‐Helix. Angewandte Chemie International Edition, 2015, 54 (37), pp.10807-10810. ⟨10.1002/ANIE.201504126⟩. ⟨hal-05770865⟩

Nicola Melis, Lorenza Ghisu, Régis Guillot, Pierluigi Caboni, Francesco Secci, et al.. Catalytic Enantioselective Synthesis of α‐(Benzylamino)cyclobutanones. European Journal of Organic Chemistry, 2015, 2015 (20), pp.4358-4366. ⟨10.1002/EJOC.201500460⟩. ⟨hal-05770921⟩

Ammar Hassoun, Claire Grison, Régis Guillot, Thomas Boddaert, David Aitken. Conformational preferences in the β-peptide oligomers of cis-2-amino-1-fluorocyclobutane-1-carboxylic acid. New Journal of Chemistry, 2015, 39 (5), pp.3270-3279. ⟨10.1039/C4NJ01929F⟩. ⟨hal-05770918⟩

2014

Eric Gloaguen, V. Brenner, M. Alauddin, B. Tardivel, M. Mons, et al.. Direct Spectroscopic Evidence of Hyperconjugation Unveils the Conformational Landscape of Hydrazides†. Angewandte Chemie International Edition, 2014, 53 (50), pp.13756-13759. ⟨10.1002/anie.201407801⟩. ⟨hal-01131234⟩

Francesca Capitta, Angelo Frongia, Jean Ollivier, David Aitken, Francesco Secci, et al.. Enantioselective Organocatalyzed Desymmetrization of 3-Substituted Cyclobutanones through Michael Addition to Nitroalkenes. SYNLETT, 2014, 26 (01), pp.123-126. ⟨10.1055/S-0034-1379489⟩. ⟨hal-05770868⟩

Hawraà Awada, Sylvie Robin, Régis Guillot, Ogaritte Yazbeck, Daoud Naoufal, et al.. Practical Syntheses of Both Enantiomers of the Conformationally Restricted GABA Analogue cis ‐(2‐Aminocyclobutyl)acetic Acid. European Journal of Organic Chemistry, 2014, 2014 (32), pp.7148-7155. ⟨10.1002/EJOC.201402676⟩. ⟨hal-05770820⟩

David Aitken, Pierluigi Caboni, Hendrik Eijsberg, Angelo Frongia, Régis Guillot, et al.. Catalytic Enantioselective Synthesis of α‐Arylaminocyclobutanones. Advanced Synthesis and Catalysis, 2014, 356 (5), pp.941-945. ⟨10.1002/ADSC.201301021⟩. ⟨hal-05770841⟩

2013

Amandine Altmayer-Henzien, Valérie Declerck, David J Aitken, Ewen Lescop, Denis Merlet, et al.. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides.. Organic & Biomolecular Chemistry, 2013, 11 (43), pp.7611-5. ⟨10.1039/c3ob41876f⟩. ⟨hal-00912800⟩

Amandine Altmayer-Henzien, Valérie Declerck, Denis Merlet, Jean-Pierre Baltaze, Jonathan Farjon, et al.. Solution State Conformational Preferences of Dipeptides Derived from N -Aminoazetidinecarboxylic Acid: An Assessment of the Hydrazino Turn. Journal of Organic Chemistry, 2013, 78 (12), pp.6031-6039. ⟨10.1021/JO400736T⟩. ⟨hal-05770757⟩

Virginie André, Marjolaine Gras, Hawraà Awada, Régis Guillot, Sylvie Robin, et al.. A unified synthesis of all stereoisomers of 2-(aminomethyl)cyclobutane-1-carboxylic acid. Tetrahedron, 2013, 69 (17), pp.3571-3576. ⟨10.1016/J.TET.2013.02.063⟩. ⟨hal-05770802⟩

Amandine Altmayer-Henzien, Valérie Declerck, Régis Guillot, David Aitken. Reactivity of 1-aminoazetidine-2-carboxylic acid during peptide forming procedures: observation of an unusual variant of the hydrazino turn. Tetrahedron Letters, 2013, 54 (8), pp.802-805. ⟨10.1016/J.TETLET.2012.11.112⟩. ⟨hal-05770767⟩

Anne Vidal, Renée Paugam, Régis Guillot, Sophie Faure, Elisabeth Pereira, et al.. Molecular structures of the photodimers of 5-phenyluracil and 6-phenyluracil. Tetrahedron Letters, 2013, 54, pp.2536-2537. ⟨hal-00819196⟩

2012

David Aitken, Angela Bernard, Francesca Capitta, Angelo Frongia, Régis Guillot, et al.. Very high stereoselectivity in organocatalyzed desymmetrizing aldol reactions of 3-substituted cyclobutanones. Organic & Biomolecular Chemistry, 2012, 10 (26), pp.5045. ⟨10.1039/C2OB25813G⟩. ⟨hal-05770681⟩

Florence Charnay-Pouget, Michael Franck, Jean-Pierre Baltaze, Elisabeth Pereira, David J Aitken. Evaluation of an Aza-Michael approach for the synthesis of 3,3-dimethyl-2-aminocyclobutane-1-carboxylic acid. ARKIVOC – Online Journal of Organic Chemistry, 2012, Part5, pp.80-93. ⟨10.3998/ark.5550190.0013.509⟩. ⟨hal-00786286⟩

Lina Juknaite, Raminta Venskutonyte, Zeinab Assaf, Sophie Faure, Thierry Gefflaut, et al.. Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors. Journal of Structural Biology, 2012, 180, pp.39-46. ⟨hal-00786246⟩

2011

David Aitken, Francesca Capitta, Angelo Frongia, Didier Gori, Régis Guillot, et al.. The First Organocatalysed Direct Aldol Reaction of 2-Hydroxycyclobutanone. SYNLETT, 2011, 2011 (05), pp.712-716. ⟨10.1055/S-0030-1259550⟩. ⟨hal-05769763⟩

David Aitken, Ludovic Drouin, Sarah Goretta, Régis Guillot, Jean Ollivier, et al.. Stereoselective preparation of β,γ-methano-GABA derivatives. Organic & Biomolecular Chemistry, 2011, 9 (21), pp.7517. ⟨10.1039/C1OB06095C⟩. ⟨hal-05769765⟩

2010

Carlos Fernandes, Sophie Faure, Elisabeth Pereira, Vincent Thery, Valérie Declerck, et al.. 12-Helix folding of cyclobutane beta-amino acid oligomers. Organic Letters, 2010, 12, pp.3606-3609. ⟨10.1021/ol101267u⟩. ⟨hal-00530671⟩

Aurélien Chevry, Marie-Laure Teyssot, Aurélie Maisonial, Pascale Lemoine, Bernard Viossat, et al.. Click Chelators – The Behavior of Platinum and Palladium Complexes in the Presence of Guanosine and DNA. European Journal of Inorganic Chemistry, 2010, 22, pp.3513-3519. ⟨10.1002/ejic.201000183⟩. ⟨hal-00530546⟩

2009

Sophie Faure, Thomas Hjelmgaard, Stéphane Roche, David J Aitken. Passerini reaction-amine deprotection-acyl migration peptide assembly: Efficient formal synthesis of Cyclotheonamide C. Organic Letters, 2009, 11, pp.1167-1170. ⟨hal-00366169⟩

Carlos Fernandes, Elisabeth Pereira, Sophie Faure, David J Aitken. Expedient preparation of all isomers of 2-Aminocyclobutanecarboxylic acid in enantiomerically pure form. Journal of Organic Chemistry, 2009, 74, pp.3217-3220. ⟨hal-00376781⟩

2008

Stéphane Roche, Sophie Roy-Faure, D.J. Aitken. Total synthesis of cyclotheonamide C using a tandem backbone-extension-coupling methodology. Angewandte Chemie International Edition, 2008, 47, pp.6840-6842. ⟨hal-00323870⟩

Aurélie Maisonial, Patrycja Serafin, Mounir Traïkia, Eric Debiton, Vincent Thery, et al.. click chelators for platinum-based anticancer drugs. European Journal of Organic Chemistry, 2008, 2008 (2), pp.298-305. ⟨10.1002/ejic.200700849⟩. ⟨hal-00204439⟩

Stéphane Roche, Sophie Faure, Lahssen El Blidi, D.J. Aitken. Total synthesis of cyclotheonamide C by use of an alpha-keto cyanophosphorane methodology for peptide assembly. European Journal of Organic Chemistry, 2008, pp.5067-5078. ⟨hal-00327190⟩

Elisabeth Pereira, Sophie Faure, David J Aitken. Photochemical behaviour of 5-formyl and 5-acetyl uracils in the presence of ethene. Tetrahedron Letters, 2008, 49, pp.1968-1970. ⟨hal-00265057⟩

Thomas Hjelmgaard, Sophie Faure, P. Lemoine, B. Viossat, David J Aitken. Rapid assembly of the polyhydroxylated b-amino acid constituents of microsclerodermins C, D et E.. Organic Letters, 2008, 10, pp.841-844. ⟨hal-00265269⟩

Aurélie Mondiere, Runhui Peng, Roland Remuson, D.J. Aitken. Efficient synthesis of 3-hydroxymethylated cis- and trans- cyclobutane b-amino acids using an intramolecular photocycloaddition strategy. Tetrahedron, 2008, 64, pp.1088-1093. ⟨10.1016/j.tet.2007.11.021⟩. ⟨hal-00204404⟩

2007

Carlos Fernandes, Christine Gauzy, Yi Yang, Olivier Roy, Elisabeth Pereira, et al.. [2 + 2] Photocycloadditions with Chiral Uracil Derivatives: Access to All Four Stereoisomers of 2-Aminocyclobutanecarboxylic Acid.. ChemInform, 2007, 38 (47), ⟨10.1002/chin.200747068⟩. ⟨hal-03093930⟩

David J Aitken, Alberto Albinati, Arnaud Gautier, Henri-Philippe Husson, Georges Morgant, et al.. Platinum(II) and palladium(II) complexes with N-aminoguanidine. European Journal of Inorganic Chemistry, 2007, pp.3327-3334. ⟨hal-00165303⟩

Thomas Hjelmgaard, Daniel Gardette, David Tanner, David J Aitken. Synthesis of (+)-coniceine via reductive photocyclization of dienamides : an entry to indolizidines. Tetrahedron: Asymmetry, 2007, 18, pp.671-678. ⟨10.1016/j.tetasy.2007.03.004⟩. ⟨hal-00141843⟩

2006

Sophie Faure, A. A. Jensen, V. Maurat, Xin Gu, Emmanuelle Sagot, et al.. Stereoselective Chemo-Enzymatic Synthesis of the Four Stereoisomers of L-2-(2-Carboxycyclobutyl)-glycine and Pharmacological Characterization at Human Excitatory Amino Acid Transporter Subtypes 1, 2 and 3.. Journal of Medicinal Chemistry, 2006, 49, pp.6532-6538. ⟨10.1021/jm060822s⟩. ⟨hal-00118392⟩

Virginie Beaufort-Droal, Elisabeth Pereira, Vincent Thery, David J Aitken. Preparation of non-racemic single-stereocentre a-aminonitriles and a study of their fate in Bruylants reactions.. Tetrahedron, 2006, 62, pp.11948-11954. ⟨10.1016/j.tet.2006.09.087⟩. ⟨hal-00118398⟩

Christine Gauzy, Bertrand Saby, Elisabeth Pereira, Sophie Faure, David J Aitken. The [2+2] photocycloaddition of uracil derivatives with ethylene as a general route to cis cyclobutane a-amino acids. SYNLETT, 2006, pp.1394-1398. ⟨hal-00118360⟩

Olivier Roy, Sophie Faure, David J Aitken. A solution to the component instability problem in the preparation of peptides containing C2 substituted cis-cyclobutane b-aminoacids: synthesis of a stable rhodopeptin analogue.. Tetrahedron Letters, 2006, 47, pp.5981-5984. ⟨10.1016/j.tetlet.2006.06.027⟩. ⟨hal-00118385⟩

David J Aitken, Isabelle Canet, Arnaud Gautier, Marlène Goubert, Jiri Kozelka, et al.. Préparation de nouveaux complexes de platine à visée antitumorale. Bulletin du Cancer, 2006, 93, pp.137-138. ⟨hal-00362020⟩

Aurélie Maisonial, Mounir Traïkia, Arnaud Gautier, David J Aitken. Control of the Platinum(II) ligating properties of rigid 1,2-diamines: the case of trans-2,3-diaminonorbornane.. Tetrahedron Letters, 2006, 47 (46), pp.8091-8093. ⟨10.1016/jtetlet.2006.09.054⟩. ⟨hal-00118388⟩

Xin Gu, Mo Xian, Sophie Roy-Faure, Jean Bolte, David J Aitken, et al.. Synthesis of the constrained glutamate analogues (2S,1 ‘ R,2 ‘ R)- and (2S,1 ‘ S,2 ‘ S)-2- (2 ‘carboxycyclobutyl)glycines L-CBG-II and L-CBG-I by enzymatic transamination. Tetrahedron Letters, 2006, 47, pp.193-196. ⟨10.1016/j.tetlet.2005.10.156⟩. ⟨hal-00017094⟩

2004

Christine Gauzy, Elisabeth Pereira, Sophie Faure, David J Aitken. Synthesis of (+)-(1S,2R) and (-)-(1R,2R)-2-aminocyclobutane-1-carboxylic acids. Tetrahedron Letters, 2004, 45, pp.7095-7097. ⟨10.1016/j.tetlet.2004.07.110⟩. ⟨hal-00135859⟩

David J Aitken, Christine Gauzy, Elisabeth Pereira. Studies on the stability of the cyclobutane b-aminoacid skeleton : a cautionary tale. Tetrahedron Letters, 2004, 45, pp.2359-2361. ⟨10.1016/j.tet.2004.01.084⟩. ⟨hal-00135852⟩

David J Aitken, Laure Besson, Françoise Fournier, Henri-Philippe Husson, Pascale Lemoine, et al.. Studies on the condensation products from N-primary 1,2-amino alcohols and formaldehyde. Heterocycles, 2004, 64, pp.277-289. ⟨hal-00135882⟩

1999

Joelle Pérard-Viret, Marc Le Bail, David J Aitken, Henri-Philippe Husson. Substitution and stereochemical effects in the reactions of combined aminonitrile-oxazolidines with a Grignard reagent. Tetrahedron Letters, 1999, 40 (29), pp.5309-5313. ⟨10.1016/S0040-4039(99)00980-6⟩. ⟨hal-03384930⟩

1997

Marc Le Bail, J. Perard-Viret, David J Aitken, Martine Bonin, Henri-Philippe Husson. Tandem reactions of organnometallic reagents with a combined aminonitrile-oxazolidine system. Tetrahedron Letters, 1997, 38 (41), pp.7177-7180. ⟨10.1016/S0040-4039(97)01704-8⟩. ⟨hal-03376790⟩

Conference papers

2019

Ariel Pérez-Mellor, Valérie Declerck, David J. Aitken, Mohammad Alauddin, Eric Gloaguen, et al.. Clustering of Flexible Chiral Molecules: Supersonic Expansion vs. Solid-State spectroscopy. International Symposium Frontiers in Cluster Science: Structure and Dynamics, Otto Dopfer, Nov 2019, Berlin (DE), Germany. ⟨hal-04335784⟩

J Donon, S Habka, T Very, V Vaquero-Vara, B Tardivel, et al.. Identification of ion pairs in solution by IR spectroscopy: crucial contributions of gas phase data and simulations. Rencontres de Chimie Physique 2019, Oct 2019, Biarritz, France. ⟨hal-03313270⟩

Ariel Pérez-Mellor, Aude Bouchet, Valérie Declerck, David J. Aitken, Mohammad Alauddin, et al.. Flexible chiral molecules: from supersonic expansions to solid-state spectroscopy. Ecole d’été du Collaborative Research Centre 1319 « ELCH » (Extreme Light for sensing and driving molecular CHirality) de l’Université de Kassel, Sep 2019, Bad Arolsen, Germany. ⟨hal-04335692⟩

Ariel Pérez-Mellor, Valérie Declerck, David J. Aitken, Anne Zehnacker. Vibrational circular dichroism study of the solid-state organisation of ring-containing peptides. Chirality 2019, Jul 2019, Bordeaux (France), France. ⟨hal-04346186⟩

2008

David J Aitken. Synthèse de beta-aminoacides, Synthèse de beta-peptides macrocycliques: Quelles Méthodologies Choisir ?. Université des Sciences et Technologies Lille 1, Oct 2008, Lille, France. ⟨hal-00345455⟩

Carlos Fernandes, Elisabeth Pereira, Sophie Roy-Faure, David J Aitken. Synthèse et étude conformationnelle de béta-peptides à motif cyclobutanique. SyCOCAL VI, Symposium de Chimie Organique en Centre-Auvergne-Limousin, Sep 2008, La Bourboule, France. ⟨hal-00322978⟩

David J Aitken. Synthèse enzymatique de monosaccharides. Université de Nice-Sophia Antipolis,, Jul 2008, Nice, France. ⟨hal-00345454⟩

David J Aitken. Méthodes originales pour la synthèse de beta-aminoacides et beta-peptides macrocycliques. SECO-45, May 2008, La Colle sur Loup, France. ⟨hal-00345453⟩

2007

David J Aitken. Alternative methodolgies for peptide synthesis: beta-aminoacids and beta-peptides as inspiration models. Faculty of Bioscience Engineering, Universiteit Gent, Nov 2007, Gent, Belgium. ⟨hal-00345446⟩

David J Aitken. béta-aminoacides: Inspiration de nouveaux concepts pour la synthèse peptidique. BioCIS, Faculté de Pharmacie de Châtenay-Malbry, Université Paris-Sud 11, Oct 2007, Châtenay-Malbry, France. ⟨hal-00345440⟩

David J Aitken, Thomas Hjelmgaard. Vers la synthèse totale de microsclerodermine D. Journées de Chimie Organiques JCO 2007, Sep 2007, Palaiseau, France. ⟨hal-00232697⟩

Sophie Roy-Faure, Stéphane Roche, David J Aitken. Synthèse totale du cyclothéonamide C. Journées de Chimie Organique JCO 2007, Sep 2007, Palaiseau, France. ⟨hal-00232738⟩

David J Aitken, Thomas Hjelmgaard. Vers la Synthèse Totale de Microsclerodermine D. Journées de Chimie Organique JCO 2007, Sep 2007, Palaiseau, France. ⟨hal-00232752⟩

Sophie Roy-Faure, Stéphane Roche, David J Aitken. Synthèse totale du Cyclothéonamide C. Journées de Chimie Organique JCO 2007, Sep 2007, Palaiseau, France. ⟨hal-00232762⟩

Carlos Fernandes, Elisabeth Pereira, Sophie Faure, David J Aitken. Unprecedented access to the parent trans-cyclobutane β-aminoacid in enantiomerically pure form. ESOC 2007, 15th European Symposium on Organic Chemistry, Jul 2007, Dublin, Ireland. ⟨hal-00506426⟩

David J Aitken. An excursion in synthetic organic photochemistry: From Orsay to Clermont… and back. SyCOCALPC-5ème Edition, May 2007, La Rochelle, France. ⟨hal-00345430⟩

David J Aitken. Alternative synthetic methodolgies for beta-aminoacid and beta-peptide synthesis. Department of Chemistry, University of Bath (Angleterre), Apr 2007, Bath, United Kingdom. ⟨hal-00345428⟩

David J Aitken. Béta-aminoacides: méthodologies synthétiques et applications à la synthèse de macrocycles peptidiques. ICOA, Université d’Orléans, Feb 2007, Orléans, France. ⟨hal-00345421⟩

David J Aitken. Beta-aminoacides: méthodologies synthétiques et applications à la synthèse de macrocycles peptidiques.. Department of Chemistry, Vrije Universiteit, Jan 2007, Amsterdam, Netherlands. ⟨hal-00345413⟩

David J Aitken. Béta-aminoacides: méthodologies synthétiques et applications à la synthèse de macrocycles peptidiques. Unviersité de Nantes, Jan 2007, Nantes, France. ⟨hal-00345412⟩

2006

David J Aitken. Beta-aminoacids: synthetic methodologies and applications in the synthesis of selected peptides. UFR Chimie, Université Louis Pasteur, Oct 2006, Strasbourg, France. ⟨hal-00345409⟩

David J Aitken. Uracil Photochemistry : an Entry to Cyclobutane Β-Aminoacids. ECHC-22 – XXII European Colloquium on Heterocyclic Chemistry, Sep 2006, Bari, Italy. ⟨hal-00136908⟩

Sophie Roy-Faure, Stéphane Roche, David J Aitken. Vers la première synthèse du Cyclothéonamide C. GECO47, Aug 2006, Merlimont, France. ⟨hal-00124140⟩

David J Aitken. Total synthesis of cyclotheonamide C: focus on the a-oxo-b-aminoacid moiety.. 16th International Conference on Organic Synthesis (ICOS 16), Jun 2006, Merida, Mexico. ⟨hal-00136849⟩

Carlos Fernandes, Daniel Gardette, Elisabeth Pereira, David J Aitken. Etude de la réactivité d’amidures d’organomagnésiens vis-à-vis d’aldéhydes aromatiques. SYCOCAL IV, May 2006, Mézières-en-Brenne, France. ⟨hal-00124178⟩

David J Aitken. B-Aminoacides : Méthodologies Synthétiques et Applications à la Synthèse de Macrocycles Peptidiques. ICSN, Mar 2006, Gif-sur-Yvette, France. ⟨hal-00136700⟩

David J Aitken, Isabelle Canet, Arnaud Gautier, Marlène Goubert, J. Kozelka, et al.. Nouveaux Complexes de Platine à Visée Antitumorale. 1ères Journées Scientifiques du CLARA (Canceropôle Lyon Auvergne Rhône Alpes), 2006, Vulcania, Saint Ours les Roches, France. ⟨hal-00021192⟩

Roland Remuson, David J Aitken. Synthèse de b-aminoacides cyclobutaniques substitués en position 3.. SYCOCAL IV, 2006, Mézières-en-Brenne, France. ⟨hal-00022018⟩

2005

Thomas Hjelmgaard, D. Gardette, D. Aitken. Enantioselective synthesis of (+)-d-coniceine by reductive photocyclisation of a dienamide. SFC Eurochem, Aug 2005, Nancy, France. ⟨hal-00128079⟩

S. P. Faure, David J Aitken, Stéphane Roche. The « MAC » approach to the total synthesis of cyclotheonamide C.. SFC Eurochem, Aug 2005, Nancy, France. ⟨hal-00128040⟩

David J Aitken, S. P. Faure, C. Gauzy, E. Pereira, B. Saby. The reaction of substituted uracils with ethylene as a general route to cyclobutane ²-aminoacids. 20th International Congress Heterocyclic Chemistry, Aug 2005, Palerme, Italy. ⟨hal-00128098⟩

Sophie Faure, David J Aitken, Stéphane Roche. Synthetic Approaches to cyclotheonamide C. 16th European Symposium on Organic Chemistry, Jul 2005, Helsinki, Finland. ⟨hal-00128810⟩

O. Roy, David J Aitken. Synthesis of a conformationally constrained rhodopeptin analogue containing a cyclobutane b-aminoacid. 6th Tetrahedron Symposium, Challenges in Organic Chemistry, Jun 2005, Bordeaux, France. ⟨hal-00128051⟩

David J Aitken. Synthetic Studies on Carbobutane b-Aminoacids and Towards the Total Synthesis of Cyclotheonamide C. ENSCP, Institut Curie, Jan 2005, Paris, France. ⟨hal-00128023⟩

2004

David J Aitken. Pulling the strings of small rings : some synthetic studies on carbocyclic aminoacids. Institute of Pharmaceutical Chemistry, Sep 2004, Szeged, Hungary. ⟨hal-00136395⟩

David J Aitken, Sophie Faure, Christine Gauzy, Elisabeth Pereira, Yi Yang. Procedures for obtaining all stereoisomers of 2-amino-1-cyclobutanecarboxylic acid from a single heterocyclic precursor. 21st European Colloquium on Heterocyclic Chemistry, Sep 2004, Sopron, Hungary. ⟨hal-00138754⟩

Virginie Beaufort, David J Aitken, F. Vergne. Reactivity of solid-supported a-aminonitriles. Journées de Chimie Organique, Sep 2004, Palaiseau, France. ⟨hal-00138717⟩

Elisabeth Pereira, David J Aitken, Virginie Beaufort, Vincent Thery. Study of Bruylants’ reaction. Journées de Chimie Organique, Sep 2004, Palaiseau, France. ⟨hal-00138706⟩

David J Aitken, Sophie Faure, Christine Gauzy, Elisabeth Pereira, Bertrand Saby. Synthèse de B-aminoacides cyclobutaniques par photocycloaddition [2+2] de dérivés de l’uracile. Journées de Chimie Organique, Sep 2004, Palaiseau, France. ⟨hal-00138702⟩

David J Aitken, Virginie Beaufort, F. Vergne. Deprotonation-alkylation reactions of solid-supported aminonitriles. 7th International Symposium on Carbanion Chemistry, Jun 2004, Alicante, Spain. ⟨hal-00138668⟩

Hélène Henon, Stéphane Azzaro, Elisabeth Pereira, Pascale Pascale Besse, P. Besse-Hoggan Besse-Hoggan, David J Aitken. D-Hydantoinase catalysed hydrolysis of 5-and 6-methyl-dihydropyrimidines : towards the synthesis of b-aminoacids. Franco-German Symposium : Bioconversions and Organic Synthesis, May 2004, Obernai, France. ⟨hal-00138632⟩

Poster communications

2025

Vincent Orève, Iman Traboulsi, Louise Ruyet, David J Aitken, Christophe Hoarau, et al.. Selective Pd-Catalyzed C(sp3)−H functionalization of 2-aminocyclobutane-1-carboxylic acids (ACBCs). European Symposium on Organic Chemistry (ESOC) 2027, Jun 2025, Copenhagen, Denmark. ⟨hal-05845152⟩

2024

F. Charnay-Pouget, J. Le Blanc Lele Fosso, L. Nauton, J.-P. Baltaze, D. J. Aitken, et al.. Peptide-peptoid hybrid oligomers incorporating cyclobutane beta-aminoacids and N-substituted beta-alanines.. NCAAs 2024 symposium, Oct 2024, Paris, France. ⟨hal-04742921⟩

Book sections

2005

David J Aitken, S. P. Faure. One or more =CC bond(s) formed by substitution or addition. Comprehensive Organic Functional Group Transformations II, Eds, Elsevier, Amsterdam, pp.531, 2005. ⟨hal-00124250⟩