Dominique Guianvarc’h

Article dans une revue

2026

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Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, et al.. Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites. Chemistry – A European Journal, In press, ⟨10.1002/chem.202503227⟩. ⟨hal-05457928⟩

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2025

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Emilie Lesur, Yijie Zhang, Nathalie Dautin, Christiane Dietrich, Ines Li de la Sierra-Gallay, et al.. Synthetic mycolates derivatives to decipher protein mycoloylation, a unique post-translational modification in bacteria. Journal of Biological Chemistry, In press, ⟨10.1016/j.jbc.2025.108243⟩. ⟨hal-04917545⟩

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Mathilde Pucher, Kirrthana Makenthirathasan, Hadrien Jalaber, Thomas Lesaux, Oliver Nüsse, et al.. Borinic Acid-Based Fluorogenic Probes as an Alternative to the Amplex Red Assay for Real-Time H 2 O 2 Monitoring in Live Cells. ACS Chemical Biology, 2025, 20 (7), pp.1574-1583. ⟨10.1021/acschembio.5c00156⟩. ⟨hal-05250768⟩

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Paulin Rollando, Emilie Lesur, Dominique Urban, Gilles Doisneau, Dominique Guianvarc’h, et al.. Synthesis of Bioorthogonal Mycolic Acids: Chemoselective Reduction of β‐Ketoesters Containing an Alkyne Using the Noyori Catalyst. European Journal of Organic Chemistry, 2025, 28 (41), pp.e202500642. ⟨10.1002/ejoc.202500642⟩. ⟨hal-05262592⟩

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Romain Sastourné-Haletou, Sacha Marynberg, Arthur Pereira, Fubao Su, Mengnuo Chen, et al.. PSL Chemical Biology Symposia: The Increasing Impact of Chemistry in Life Sciences. ChemBioChem, 2025, 26 (10), pp.e202500231. ⟨10.1002/cbic.202500231⟩. ⟨hal-05343650⟩

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2024

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Cécile Labarre, Yijie Zhang, Emilie Lesur, Marie Ley, Laila Sago, et al.. Bioorthogonal Monomycolate of Trehalose Disclosed the O -Mycoloylation of Mycoloyltransferases and Other Cell Envelope Proteins in C. glutamicum. ACS Chemical Biology, 2024, 19 (11), pp.2359-2371. ⟨10.1021/acschembio.4c00502⟩. ⟨hal-04917513⟩

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Carole Saintomé, Océane Monfret, Gilles Doisneau, Dominique Guianvarc’h. Oligonucleotide‐Based Photoaffinity Probes: Chemical Tools and Applications for Protein Labeling. ChemBioChem, 2024, 25 (19), pp.e202400097. ⟨10.1002/cbic.202400097⟩. ⟨hal-05251435⟩

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2023

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Leeroy Baron, Justine Hadjerci, Leishemba Thoidingjam, Marina Plays, Romain Bucci, et al.. PSL Chemical Biology Symposia Third Edition: A Branch of Science in its Explosive Phase. ChemBioChem, 2023, 24 (8), pp.e202300093. ⟨10.1002/cbic.202300093⟩. ⟨hal-04092530⟩

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Alexandra Bristiel, Manon Cadinot, Mathieu Pizzonero, Frédéric Taran, Dominique Urban, et al.. 2′-Modified thymidines with bioorthogonal cyclopropene or sydnone as building blocks for copper-free postsynthetic functionalization of chemically synthesized oligonucleotides. Bioconjugate Chemistry, 2023, 34 (9), pp.1613-1621. ⟨10.1021/acs.bioconjchem.3c00284⟩. ⟨hal-04281606⟩

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Emilie Lesur, Paulin Rollando, Dominique Guianvarc’h, Yann Bourdreux. Synthesis of trehalose-based chemical tools for the study of the mycobacterial membrane. Comptes Rendus. Chimie, 2023, 26 (S3), pp.17-38. ⟨10.5802/crchim.246⟩. ⟨hal-05261705⟩

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D. Liu, O. Monfret, Y. Bourdreux, D. Urban, D. Guianvarc’h, et al.. Fast Access to 5-Hydroxymethyl Derivatives of 2′-Deoxyuridine Promoted by Acidic Amberlyst 15 Resin. SYNLETT, 2023, 34 (02), pp.137-142. ⟨10.1055/a-1961-7251⟩. ⟨hal-04047031⟩

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Océane Monfret, Dan Liu, Paulin Rollando, Yann Bourdreux, Dominique Urban, et al.. Preparation of 5‐Hydroxymethyl‐pyrimidine Based Nucleosides: A Reinvestigation. European Journal of Organic Chemistry, 2023, 26 (28), ⟨10.1002/ejoc.202300298⟩. ⟨hal-04281656⟩

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2022

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Mathieu Carlier, Emilie Lesur, Aurélie Baron, Aurélie Lemétais, Karine Guitot, et al.. Synthesis of chemical tools to label the mycomembrane of corynebacteria using modified iron( iii ) chloride-mediated protection of trehalose. Organic & Biomolecular Chemistry, 2022, 20 (9), pp.1974-1981. ⟨10.1039/D2OB00107A⟩. ⟨hal-03801948⟩

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Blaise Gatin-Fraudet, Mathilde Pucher, Thomas Le Saux, Gilles Doisneau, Yann Bourdreux, et al.. Hydrogen peroxide-responsive triggers based on borinic acids: molecular insights into the control of oxidative rearrangement. Chemistry – A European Journal, In press, 28 (59), pp.e202201543. ⟨10.1002/chem.202201543⟩. ⟨hal-03752143⟩

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2021

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Blaise Gatin-Fraudet, Roxane Ottenwelter, Thomas Le Saux, Stéphanie Norsikian, Mathilde Pucher, et al.. Evaluation of borinic acids as new, fast hydrogen peroxide–responsive triggers. Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (50), pp.e2107503118. ⟨10.1073/pnas.2107503118⟩. ⟨hal-03542546⟩

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Arnaud Gautier, Maria Duca, Estelle Léonard, Dominique Guianvarc’h, Boris Vauzeilles, et al.. Chémobiologie et maladies infectieuses : de Pasteur à la COVID-19.. L’Actualité Chimique, 2021, 463. ⟨hal-03845179⟩

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2019

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Emilie Lesur, Aurélie Baron, Christiane Dietrich, Marie Buchotte, Gilles Doisneau, et al.. First access to a mycolic acid-based bioorthogonal reporter for the study of the mycomembrane and mycoloyltransferases in Corynebacteria. Chemical Communications, 2019, 55 (87), pp.13074-13077. ⟨10.1039/C9CC05754D⟩. ⟨hal-04388218⟩

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2018

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Romain Brisse, Dominique Guianvarc’h, Christelle Mansuy, Sandrine Sagan, David Kreher, et al.. Probing the in-air growth of large area of 3D functional structures into a 2D supramolecular nanoporous network. Chemical Communications, 2018, 54 (72), pp.10068-10071. ⟨10.1039/c8cc06125d⟩. ⟨hal-01969600⟩

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Sébastien Cardon, Emmanuelle Sachon, Ludovic Carlier, Thierry Drujon, Astrid Walrant, et al.. Peptidoglycan potentiates the membrane disrupting effect of the carboxyamidated form of DMS-DA6, a Gram-positive selective antimicrobial peptide isolated from Pachymedusa dacnicolor skin. PLoS ONE, 2018, 13 (10), pp.e0205727. ⟨10.1371/journal.pone.0205727⟩. ⟨hal-02346622⟩

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Tom Gérard-Hirne, Frédéric Thiebaut, Emmanuelle Sachon, Alexandre Désert, Thierry Drujon, et al.. Photoactivatable oligonucleotide probes to trap single-stranded DNA binding proteins: Updating the potential of 4-thiothymidine from a comparative study. Biochimie, 2018, 154, pp.164-175. ⟨10.1016/j.biochi.2018.08.007⟩. ⟨hal-03970700⟩

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Ludovic Halby, Nils Marechal, Dany Pechalrieu, Vincent Cura, Don-Marc Franchini, et al.. Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors. Philosophical Transactions of the Royal Society B: Biological Sciences, 2018, 373 (1748), pp.20170072. ⟨10.1098/rstb.2017.0072⟩. ⟨hal-02094589⟩

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2017

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Karine Guitot, Thierry Drujon, Fabienne Burlina, Sandrine Sagan, Sandra Beaupierre, et al.. A direct label-free MALDI-TOF mass spectrometry based assay for the characterization of inhibitors of protein lysine methyltransferases. Analytical and Bioanalytical Chemistry, 2017, 409 (15), pp.3767-3777. ⟨10.1007/s00216-017-0319-5⟩. ⟨hal-01536705⟩

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Ludovic Halby, Yoann Menon, Elodie Rilova, Dany Pechalrieu, Véronique Masson, et al.. Rational Design of Bisubstrate-Type Analogues as Inhibitors of DNA Methyltransferases in Cancer Cells. Journal of Medicinal Chemistry, 2017, 60 (11), pp.4665-4679. ⟨10.1021/acs.jmedchem.7b00176⟩. ⟨hal-04961079⟩

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2015

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Cecile Desjobert, Mounir El Mai, Tom Gerard-Hirne, Dominique Guianvarc’h, Arnaud Carrier, et al.. Combined analysis of DNA methylation and cell cycle in cancer cells. Epigenetics, 2015, 10 (1), pp.82-91. ⟨10.1080/15592294.2014.995542⟩. ⟨hal-01365337⟩

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2014

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Dominique Guianvarc’h, Paola B Arimondo. Challenges in developing novel DNA methyltransferase inhibitors for cancer therapy. Future Medicinal Chemistry, 2014, 6 (11), pp.1237-1240. ⟨10.4155/FMC.14.82⟩. ⟨hal-01365345⟩

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Karine Guitot, Silvia Scarabelli, Thierry Drujon, Gérard Bolbach, Mehdi Amoura, et al.. Label-free measurement of histone lysine methyltransferases activity by MALDI-TOF mass spectrometry.. Analytical Biochemistry, 2014, 456, pp.25-31. ⟨10.1016/j.ab.2014.04.006⟩. ⟨hal-00982533⟩

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2013

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Saâdia Asgatay, Christine Champion, Gaël Marloie, Thierry Drujon, Catherine Senamaud-Beaufort, et al.. Synthesis and Evaluation of Analogues of N-Phthaloyl-L-tryptophan (RG108) as Inhibitors of DNA Methyltransferase 1.. Journal of Medicinal Chemistry, 2013, 57 (2), pp.421-434. ⟨10.1021/jm401419p⟩. ⟨hal-00920710⟩

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Alexandre Ceccaldi, Arumugam Rajavelu, Sergey Ragozin, Catherine Sénamaud-Beaufort, Pavel Bashtrykov, et al.. Identification of Novel Inhibitors of DNA Methylation by Screening of a Chemical Library.. ACS Chemical Biology, 2013, 8 (3), pp.543-548. ⟨10.1021/cb300565z⟩. ⟨hal-00777786⟩

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Guangqi E, Thierry Drujon, Isabelle Correia, Olivier Ploux, Dominique Guianvarc’h. An active site mutant of Escherichia coli cyclopropane fatty acid synthase forms new non-natural fatty acids providing insights on the mechanism of the enzymatic reaction. Biochimie, 2013, 95 (12), pp.2336-2344. ⟨10.1016/j.biochi.2013.08.007⟩. ⟨hal-02467802⟩

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E. Guangqi, Thierry Drujon, Isabelle Correia, Olivier Ploux, Dominique Guianvarc’h. An active site mutant of Escherichia coli cyclopropane fatty acid synthase forms new non-natural fatty acids providing insights on the mechanism of the enzymatic reaction.. Psychological Science, 2013, 95 (12), pp.2336-2344. ⟨10.1016/j.biochi.2013.08.007⟩. ⟨hal-00860261⟩

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2012

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Ludovic Halby, Christine Champion, Catherine Sénamaud-Beaufort, Sophie Ajjan, Thierry Drujon, et al.. Rapid synthesis of new DNMT inhibitors derivatives of procainamide.. ChemBioChem, 2012, 13 ((1)), pp.157-65. ⟨10.1002/cbic.201100522⟩. ⟨hal-00680950⟩

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Lucrèce Matheron, Séverine Clavier, Oumar Diebate, Philippe Karoyan, Gérard Bolbach, et al.. Improving the Selectivity of the Phosphoric Acid β-Elimination on a Biotinylated Phosphopeptide.. Journal of The American Society for Mass Spectrometry, 2012, 23 (11), pp.1981-1990. ⟨10.1007/s13361-012-0467-y⟩. ⟨hal-00730383⟩

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Pierre Vekhoff, Maria Duca, Dominique Guianvarc’h, Rachid Benhida, Paola B Arimondo. Sequence-specific base pair mimics are efficient topoisomerase IB inhibitors.. Biochemistry, 2012, 51 ((1)), pp.43-51. ⟨10.1021/bi2012959⟩. ⟨hal-00683339⟩

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2011

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Alexandre Ceccaldi, Arumugam Rajavelu, Christine Champion, Christine Rampon, Renata Z. Jurkowska, et al.. C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development.. ChemBioChem, 2011, (12) (9), pp.1337-45. ⟨10.1002/cbic.201100130⟩. ⟨hal-00632453⟩

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Maud Larregola, Olivier Lequin, Philippe Karoyan, Dominique Guianvarc’h, Solange Lavielle. β-Amino acids containing peptides and click-cyclized peptide as β-turn mimics: a comparative study with ‘conventional’ lactam- and disulfide-bridged hexapeptides.. Journal of Peptide Science, 2011, 17 ((9)), pp.632-43. ⟨10.1002/psc.1382⟩. ⟨hal-00642781⟩

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2010

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Christine Champion, Dominique Guianvarc’h, Catherine Sénamaud-Beaufort, Renata Z Jurkowska, Albert Jeltsch, et al.. Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine.. PLoS ONE, 2010, 5 (8), pp.e12388. ⟨10.1371/journal.pone.0012388⟩. ⟨hal-00627422⟩

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2008

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Dominique Guianvarc’h, E Guangqi, Thierry Drujon, Camille Rey, Qian Wang, et al.. Identification of inhibitors of the E. coli cyclopropane fatty acid synthase from the screening of a chemical library: In vitro and in vivo studies.. Biochimica et Biophysica Acta – Molecular Cell Research, 2008, 1764 (11), pp.1381-1388. ⟨10.1016/j.bbapap.2008.04.019⟩. ⟨hal-00294830⟩

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2006

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P.B. Arimondo, C.J. Thomas, K. Oussedik, B. Baldeyrou, C. Mahieu, et al.. Exploring the Cellular Activity of Camptothecin-Triple-Helix-Forming Oligonucleotide Conjugates.. Molecular and Cellular Biology, 2006, 26, pp.324-333. ⟨hal-00017190⟩

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M. Duca, Dominique Guianvarc’h, K. Oussedik, L. Halby, A. Garbesi, et al.. Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides.. Nucleic Acids Research, 2006, 34(6), pp.1900-1911. ⟨hal-00120822⟩

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Dominique Guianvarc’h, T. Drujon, T. Ear Leang, Francis F. Courtois, O. Ploux. Identification of new inhibitors of E. coli cyclopropane fatty acid synthase using a colorimetric assay.. BBA – Biochimica et Biophysica Acta, 2006, 1764(8), pp.1381-1388. ⟨hal-00120819⟩

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2005

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M.L. Capobianco, Champdore M. De, F. Arcamone, A. Garbesi, Dominique Guianvarc’h, et al.. Improved synthesis of daunomycin conjugates with triplex-forming oligonucleotides. The polypurine tract of HIV-1 as a target.. Bioorganic and Medicinal Chemistry, 2005, 13(9), pp.3209-3218. ⟨hal-00017180⟩

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M. Duca, K. Oussedik, A. Ceccaldi, L. Halby, Dominique Guianvarc’h, et al.. Triple helix-forming oligonucleotides conjugated to new inhibitors of topoisomerase II: synthesis and binding properties.. Bioconjugate Chemistry, 2005, 16(4), pp.873-884. ⟨hal-00017182⟩

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M. Duca, Dominique Guianvarc’h, P. Meresse, E. Bertounesque, Daniel Dauzonne, et al.. Synthesis and biological study of a new series of 4′-O-Demethyl-epipodophyllotoxin derivatives.. Journal of Medicinal Chemistry, 2005, 48(2), pp.593-603. ⟨hal-00017177⟩

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2004

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N. Craynest Van, Dominique Guianvarc’h, Corinne Peyron, R. Benhida. Efficient Synthesis of Extended Guanine Analogues Designed for Recognition of an A*T Inverted Base Pair in Triple Helix-based Strategy.. Tetrahedron Letters, 2004, 45, pp.6243-6247. ⟨hal-00142452⟩

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Dominique Guianvarc’h, M. Duca, C. Boukarim, L. Kraus-Berthier, S. Leonce, et al.. Synthesis and Biological Activity of Sulfonamide Derivatives of Epipodophyllotoxin.. Journal of Medicinal Chemistry, 2004, 47 (9), pp.2365-2374. ⟨hal-00142450⟩

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Chapitre d’ouvrage

2022

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Alexandre Désert, Karine Guitot, Audrey Michaud, Daniel Holoch, Raphaël Margueron, et al.. Characterization of SET-Domain Histone Lysine Methyltransferase Substrates Using a Cofactor S-Adenosyl-l-Methionine Surrogate. Histone Methyltransferases, 2529, Springer US, pp.297-311, 2022, Methods in Molecular Biology, ⟨10.1007/978-1-0716-2481-4_14⟩. ⟨hal-03752402⟩

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2021

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Dominique Guianvarc’h, Yann Bourdreux, Christophe Biot, Boris Vauzeilles. Metabolic Labeling of Bacterial Glycans. Spencer Williams. Comprehensive Glycoscience 2nd ed, Volume 3 : Cellular Glycobiology, 3, Elsevier, pp.303-328, 2021, 978-0-12-822244-7. ⟨10.1016/b978-0-12-819475-1.00098-5⟩. ⟨hal-03400516⟩

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2016

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Alexandre Erdmann, Paola B. Arimondo, Dominique Guianvarc’h. Structure-Guided Optimization of DNA Methyltransferase Inhibitors. MedinaFranco, JL. EPI-INFORMATICS: DISCOVERY AND DEVELOPMENT OF SMALL MOLECULE EPIGENETIC DRUGS AND PROBES, ELSEVIER ACADEMIC PRESS INC, pp.53-73, 2016, 978-0-12-802808-7. ⟨10.1016/B978-0-12-802808-7.00003-4⟩. ⟨hal-01365334⟩

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Notice d’encyclopédie ou de dictionnaire

2022

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Dominique Guianvarc’h, Christophe Biot, Boris Vauzeilles. Prix Nobel de Chimie 2022. Encyclopædia Universalis, 2022. ⟨hal-04519017⟩

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Brevet

2011

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A, Ceccaldi, C. Sénamaud-Beaufort, R, Jurkowska, N. Gagey, V, Dumontet, et al.. Flavones and flavanones derivates as DNA methyltransferases inhibitors… Patent n° : EP09305840. 2011. ⟨hal-00641369⟩

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Poster de conférence

2025

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Mathilde Pucher, Léa Madegard, Kirrthana Makenthirathasan, Hadrien Jalaber, Thomas Le Saux, et al.. Real-time monitoring oh H2O2 in live cells with novel borinic acid-based fluorogenic probes as an alternative to the Amplex Red assay. Noxros2025: Stress oxydant & régulation rédox dans le Vivant, Nov 2025, Marrakech, Morocco. ⟨hal-05462211⟩

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Dominique Urban, Léa Madegard, Marie Erard, Oliver Nüsse, Dominique Guianvarc’h. Applying the HALO-Tag strategy to specifically target new borinic acids as hydrogen peroxide-responsive probes to proteins. ChemBioParis2025, Oct 2025, Sorbonne Université (Paris), France. ⟨hal-05395345⟩

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Dominique Urban, Marie Erard, Oliver Nüsse, Léa Madegard, Dominique Guianvarc’h. Targeting proteins with novel hydrogen peroxide-responsive borinic acid probes using HALO-Tag strategy. Journées de Chimie Organique – (JCO2025), Oct 2025, Palaiseau (91), France. ⟨hal-05394585⟩

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2024

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Léa Madegard, Marie Erard, Oliver Nüsse, Dominique Guianvarc’h, Dominique Urban. Borinic acids as hydrogen peroxide-responsive probes. RECOB19, Mar 2024, Aussois (France), France. ⟨hal-05395398⟩

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Léa Madegard, Marie Erard, Oliver Nüsse, Dominique Guianvarc’h, Dominique Urban. Specific targeting of new borinic acids as hydrogen peroxide-responsive probes to proteins using HALO-Tag strategy. PhysChemCell, Oct 2024, Université Paris-Saclay, Orsay, France. ⟨hal-05395370⟩

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