Institut de Chimie Moléculaire et des Matériaux d Orsay
Bat 670
17 Av. des Sciences
91190 Orsay
Louis-Antoine Barel
Teaching Researcher
Bioorganic and Bioinorganic Chemistry, NMR Methodology
Bioorganic and Bioinorganic Chemistry, NMR Methodology
louis-antoine.barel@-Code to remove to avoid SPAM-universite-paris-saclay.fr
After receiving his PhD in 2019 under the supervision of Dr. Laurence Mulard (Institut Pasteur – Université Paris Cité), focusing on the synthesis of glycoconjugate-based vaccines, Louis-Antoine Barel further specialized in glycochemistry and synthetic organic chemistry through two postdoctoral fellowships (ICMPE – CNRS de Thiais, University College Dublin, Ireland) and a position as Temporary Teaching and Research Assistant (ATER) at Université de Paris-Est Créteil.
In 2025, he joined Université Paris-Saclay as an Assistant Professor (Maître de Conférence) at the ICMMO, within the Chimie Bioorganique-Bioinorganique, Méthodologie RMN (CB2MR) team. His research focuses on the development of novel digital approaches towards the prediction and optimization of glycosylation reactions. By combining experimental and structural data, his work aims to standardize and exploit chemical datasets for the development of Artificial Intelligence-based tools capable of predicting reaction reactivity, selectivity, and outcomes, ultimately providing decision-support systems for synthetic chemists.
In 2025, he joined Université Paris-Saclay as an Assistant Professor (Maître de Conférence) at the ICMMO, within the Chimie Bioorganique-Bioinorganique, Méthodologie RMN (CB2MR) team. His research focuses on the development of novel digital approaches towards the prediction and optimization of glycosylation reactions. By combining experimental and structural data, his work aims to standardize and exploit chemical datasets for the development of Artificial Intelligence-based tools capable of predicting reaction reactivity, selectivity, and outcomes, ultimately providing decision-support systems for synthetic chemists.
Journal articles
2024
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- Juliette Bréhat, Shirin Leick, Julien Musman, Jin Bo Su, Nicolas Eychenne, et al.. Identification of a mechanism promoting mitochondrial sterol accumulation during myocardial ischemia–reperfusion: role of TSPO and STAR. Basic Research in Cardiology, In press, Online ahead of print. ⟨10.1007/s00395-024-01043-3⟩. ⟨hal-04539472⟩
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2023
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- Shruti Mohan, Louis-Antoine Barel, Djamal Eddine Benrahla, Bernard Do, Qiyue Mao, et al.. Development of carbon monoxide-releasing molecules conjugated to polysaccharides (glyco-CORMs) for delivering CO during obesity. Pharmacological Research, 2023, 191, pp.106770. ⟨10.1016/j.phrs.2023.106770⟩. ⟨hal-04168490⟩
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2021
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- Mounir Benkoulouche, Akli Ben Imeddourene, Louis-Antoine Barel, Dorian Lefebvre, Mathieu Fanuel, et al.. Computer-aided engineering of a branching sucrase for the glucodiversification of a tetrasaccharide precursor of S. flexneri antigenic oligosaccharides. Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-99384-9⟩. ⟨hal-03382404⟩
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- Mounir Benkoulouche, Akli Ben Imeddourene, Louis-Antoine Barel, Guillaume Le Heiget, Sandra Pizzut, et al.. Redirecting substrate regioselectivity using engineered ΔN123-GBD-CD2 branching sucrases for the production of pentasaccharide repeating units of S. flexneri 3a, 4a and 4b haptens. Scientific Reports, 2021, 11, ⟨10.1038/s41598-021-81719-1⟩. ⟨hal-03139892⟩
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- Hu Zhaoyu, Mounir Benkoulouche, Louis-Antoine Barel, Guillaume Le Heiget, Akli Ben Imeddourene, et al.. A convergent chemoenzymatic strategy to deliver a diversity of Shigella flexneri serotype-specific O-antigen segments from a unique lightly protected tetrasaccharide core. Journal of Organic Chemistry, 2021, 86 (3), pp.2058-2075. ⟨10.1021/acs.joc.0c00777⟩. ⟨hal-03020947⟩
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2019
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- Louis-Antoine Barel, Laurence A. Mulard. Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in human. Human Vaccines & Immunotherapeutics, 2019, 15 (6), pp.1338-1356. ⟨10.1080/21645515.2019.1606972⟩. ⟨hal-02916015⟩
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Conference papers
2019
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- Mounir Benkoulouche, Akli Ben Imeddourene, Louis-Antoine Barel, Zhaoyu Hu, Guillaume Le Heiget, et al.. Enzymatic glucosylation of a chemically-protected tetrasaccharide to access antigenic oligosaccharides. CBM13, May 2019, Toulouse, France. ⟨hal-04786208⟩
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Patents
2023
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- Laurence A Mulard, Guillaume Le Heiget, Hu Zhaoyu, Louis-Antoine Barel, Isabelle André, et al.. Protected tetrasaccharides, their process of preparation and their use in the synthesis of bacterial oligosaccharides. France, Patent n° : US20240002423A1. 2023. ⟨hal-04780428⟩
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